PDF(Pubmed)
Abstract：
Cancer has been one of the most problematic health issues globally. Typically, all cancers share a common characteristic or cancer hallmark, such as sustaining cell proliferation, evading growth suppressors, and enabling replicative immortality. Indeed, cell cycle regulation in cancer is often found to be dysregulated, leading to an increase in aggressiveness. These dysregulations are partly due to the aberrant cellular signaling pathway. In recent years, circular RNAs (circRNAs) have been widely studied and classified as one of the regulators in various cancers. Numerous studies have reported that circRNAs antagonize or promote cancer progression through the modulation of cell cycle regulators or their associated signaling pathways, directly or indirectly. Mostly, circRNAs are known to act as microRNA (miRNA) sponges. However, they also hold additional mechanisms for regulating cellular activity, including protein binding, RNA-binding protein (RBP) recruitment, and protein translation. This review will discuss the current knowledge of how circRNAs regulate cell cycle-related proteins through the abovementioned mechanisms in different cancers.
摘要：
癌症一直是全球最棘手的健康问题之一。通常,所有癌症都有共同的特征或癌症标志，例如维持细胞增殖，逃避生长抑制因子，并实现复制永生。的确,癌症中的细胞周期调节经常被发现失调，导致侵略性的增加。这些失调部分是由于异常的细胞信号传导途径。近年来,环状RNA（circularRNAs，circularRNAs）已被广泛研究，并被归类为各种癌症的调节因子之一。大量研究报道circRNAs通过调节细胞周期调节因子或其相关信号通路拮抗或促进癌症进展。直接或间接。大多数情况下,已知circRNAs充当microRNA(miRNA)海绵。然而,它们还拥有调节细胞活动的额外机制，包括蛋白质结合，RNA结合蛋白（RBP）募集，蛋白质翻译这篇综述将讨论circRNAs如何通过上述机制在不同癌症中调节细胞周期相关蛋白的最新知识。
