PDF(Pubmed)
Abstract：
Psoriasis is a chronic autoimmune inflammatory skin disorder that affects approximately 2-3% of the global population due to significant genetic predisposition. It is characterized by an uncontrolled growth and differentiation of keratinocytes, leading to the formation of scaly erythematous plaques. Psoriasis extends beyond dermatological manifestations to impact joints and nails and is often associated with systemic disorders. Although traditional treatments provide relief, their use is limited by potential side effects and the chronic nature of the disease. This review aims to discuss the therapeutic potential of keratinocyte-targeting natural products in psoriasis and highlight their efficacy and safety in comparison with conventional treatments. This review comprehensively examines psoriasis pathogenesis within keratinocytes and the various related signaling pathways (such as JAK-STAT and NF-κB) and cytokines. It presents molecular targets such as high-mobility group box-1 (HMGB1), dual-specificity phosphatase-1 (DUSP1), and the aryl hydrocarbon receptor (AhR) for treating psoriasis. It evaluates the ability of natural compounds such as luteolin, piperine, and glycyrrhizin to modulate psoriasis-related pathways. Finally, it offers insights into alternative and sustainable treatment options with fewer side effects.
摘要：
牛皮癣是一种慢性自身免疫性炎症性皮肤病，由于明显的遗传易感性，影响全球约2-3％的人口。它的特征是角质形成细胞不受控制的生长和分化，导致鳞状红斑的形成。牛皮癣超出皮肤病学表现而影响关节和指甲，并且通常与全身性疾病有关。虽然传统的治疗方法提供了救济，它们的使用受到潜在副作用和疾病慢性性质的限制。本文旨在讨论角质形成细胞靶向天然产物在银屑病中的治疗潜力，并强调其与常规治疗相比的有效性和安全性。本文综述了银屑病在角质形成细胞中的发病机制以及各种相关的信号通路（如JAK-STAT和NF-κB）和细胞因子。它提出了分子靶标，如高迁移率基团盒-1（HMGB1），双特异性磷酸酶-1（DUSP1），和用于治疗银屑病的芳香烃受体(AhR)。它评估了天然化合物如木犀草素的能力，胡椒碱,和甘草酸调节银屑病相关途径。最后,它提供了更少副作用的替代和可持续治疗方案的见解。
