PDF(Pubmed)
Abstract：
In the face of the SARS-CoV-2 pandemic, characterized by the virus\'s rapid mutation rates, developing timely and targeted therapeutic and diagnostic interventions presents a significant challenge. This study utilizes bioinformatic analyses to pinpoint conserved genomic regions within SARS-CoV-2, offering a strategic advantage in the fight against this and future pathogens. Our approach has enabled the creation of a diagnostic assay that is not only rapid, reliable, and cost-effective but also possesses a remarkable capacity to detect a wide array of current and prospective variants with unmatched precision. The significance of our findings lies in the demonstration that focusing on these conserved genomic sequences can significantly enhance our preparedness for and response to emerging infectious diseases. By providing a blueprint for the development of versatile diagnostic tools and therapeutics, this research paves the way for a more effective global pandemic response strategy.
摘要：
面对SARS-CoV-2大流行,以病毒的快速突变率为特征，制定及时和有针对性的治疗和诊断干预措施是一个重大挑战。这项研究利用生物信息学分析来确定SARS-CoV-2中的保守基因组区域，在对抗这种病原体和未来病原体方面提供了战略优势。我们的方法使得能够创建不仅快速，可靠,并且具有成本效益，但也具有显着的能力，以无与伦比的精度检测广泛的当前和未来的变体。我们发现的意义在于证明，关注这些保守的基因组序列可以显着增强我们对新出现的传染病的准备和反应。通过为多功能诊断工具和疗法的开发提供蓝图，这项研究为更有效的全球流行病应对策略铺平了道路。
