PDF(Pubmed)
Abstract：
Wound infections caused by opportunistic bacteria promote persistent infection and represent the main cause of delayed healing. Probiotics are acknowledged for their beneficial effects on the human body and could be utilized in the management of various diseases. They also possess the capacity to accelerate wound healing, due to their remarkable anti-pathogenic, antibiofilm, and immunomodulatory effects. Oral and topical probiotic formulations have shown promising openings in the field of dermatology, and there are various in vitro and in vivo models focusing on their healing mechanisms. Wound dressings embedded with prebiotics and probiotics are now prime candidates for designing wound healing therapeutic approaches to combat infections and to promote the healing process. The aim of this review is to conduct an extensive scientific literature review regarding the efficacy of oral and topical probiotics in wound management, as well as the potential of wound dressing embedding pre- and probiotics in stimulating the wound healing process.
摘要：
由机会性细菌引起的伤口感染促进持续性感染并且是延迟愈合的主要原因。益生菌因其对人体的有益作用而被公认，可用于治疗各种疾病。它们还具有加速伤口愈合的能力，由于它们显著的抗致病性，抗生物膜,和免疫调节作用。口服和局部益生菌制剂在皮肤病学领域显示出有希望的开口，并且有各种体外和体内模型专注于它们的愈合机制。嵌入有益生元和益生菌的伤口敷料现在是设计伤口愈合治疗方法以对抗感染和促进愈合过程的主要候选者。这篇综述的目的是对口腔和局部益生菌在伤口管理中的功效进行广泛的科学文献综述。以及伤口敷料包埋前和益生菌在刺激伤口愈合过程中的潜力。
