PDF(Pubmed)
Abstract：
It is remarkable how teeth maintain their healthy condition under exceptionally high levels of mechanical loading. This suggests the presence of inherent mechanical adaptation mechanisms within their structure to counter constant stress. Dentin, situated between enamel and pulp, plays a crucial role in mechanically supporting tooth function. Its intermediate stiffness and viscoelastic properties, attributed to its mineralized, nanofibrous extracellular matrix, provide flexibility, strength, and rigidity, enabling it to withstand mechanical loading without fracturing. Moreover, dentin\'s unique architectural features, such as odontoblast processes within dentinal tubules and spatial compartmentalization between odontoblasts in dentin and sensory neurons in pulp, contribute to a distinctive sensory perception of external stimuli while acting as a defensive barrier for the dentin-pulp complex. Since dentin\'s architecture governs its functions in nociception and repair in response to mechanical stimuli, understanding dentin mechanobiology is crucial for developing treatments for pain management in dentin-associated diseases and dentin-pulp regeneration. This review discusses how dentin\'s physical features regulate mechano-sensing, focusing on mechano-sensitive ion channels. Additionally, we explore advanced in vitro platforms that mimic dentin\'s physical features, providing deeper insights into fundamental mechanobiological phenomena and laying the groundwork for effective mechano-therapeutic strategies for dentinal diseases.
摘要：
值得注意的是，牙齿在异常高的机械负荷下如何保持健康状况。这表明在其结构中存在固有的机械适应机制以抵抗恒定的应力。Dentin,位于搪瓷和纸浆之间，在机械支撑牙齿功能中起着至关重要的作用。其中等刚度和粘弹性，归因于它的矿化，纳米纤维细胞外基质，提供灵活性，力量,和刚性，使其能够承受机械载荷而不会破裂。此外，牙本质的独特建筑特征，如牙本质小管内的成牙本质过程和牙本质中的成牙本质细胞与牙髓中的感觉神经元之间的空间分隔，有助于外部刺激的独特感官感知，同时充当牙本质牙髓复合体的防御屏障。由于牙本质的结构控制着其在响应机械刺激的伤害感受和修复中的功能，了解牙本质机械生物学对于开发牙本质相关疾病和牙本质牙髓再生的疼痛管理治疗至关重要。这篇综述讨论了牙本质的物理特征如何调节机械感应，专注于机械敏感离子通道。此外,我们探索先进的体外平台，模仿牙本质的物理特征，提供对基本机械生物学现象的更深入的见解，并为牙本质疾病的有效机械治疗策略奠定基础。
