PDF(Pubmed)
Abstract：
Fibroblast growth factor (FGF)-23 is a phosphaturic hormone. An association between increasing FGF-23 levels and progression of chronic kidney disease (CKD) was documented in cats, dogs, and humans. The information regarding reference intervals (RIs) of FGF-23 in cats is limited. We aimed to establish RIs in a large cohort of clinically healthy cats and to investigate correlations with sex and age. A total of 118 cats with unremarkable complete blood count and serum chemistry profile were included. Clinically sick cats, cats with concurrent diseases, suspicion of CKD, or receiving renal diets were excluded. FGF-23 concentrations were measured with the FGF-23 ELISA Kit. RIs were calculated using the reference interval advisor software 2.1 (Microsoft Excel). FGF-23 concentrations were correlated with sex and age. The RI for FGF-23 concentrations spanned 85.8 to 387.0 pg/mL (90% confidence interval: lower limit 40.5 to 103.9 pg/mL, upper limit: 354.6 to 425.0 pg/mL). No significant relationships (r2 = 0.044) were detected with age (p = 0.081) or sex (p = 0.191). Other studies of the same diagnostic assay calculated RIs of 56 to 700 pg/mL in 79 cats and <336 pg/mL in 108 cats, and in concordance with the present study, did not detect any correlation with sex or age.
摘要：
成纤维细胞生长因子(FGF)-23是一种磷性激素。增加的FGF-23水平和慢性肾病（CKD）的进展之间的关联被记录在猫，狗,和人类。关于猫中FGF-23的参考间隔(RI)的信息是有限的。我们的目的是在一大群临床健康的猫中建立RIs，并调查与性别和年龄的相关性。包括总共118只具有不显著的全血细胞计数和血清化学特征的猫。临床上生病的猫，患有并发疾病的猫，怀疑CKD,或接受肾脏饮食被排除在外。用FGF-23ELISA试剂盒测量FGF-23浓度。使用参考间隔顾问软件2.1(MicrosoftExcel)计算RI。FGF-23浓度与性别和年龄相关。FGF-23浓度的RI跨越85.8至387.0pg/mL（90％置信区间：下限40.5至103.9pg/mL，上限：354.6至425.0pg/mL）。未检测到与年龄（p=0.081）或性别（p=0.191）的显着关系（r2=0.044）。相同的诊断测定的其他研究计算出79只猫的RIs为56至700pg/mL，108只猫的RIs<336pg/mL，与目前的研究一致，没有检测到与性别或年龄的任何相关性。
