PDF(Pubmed)
Abstract：
Inflammatory bowel disease (IBD) is a chronic disease characterized by different cell infiltrates in the intestine. The aims of this study were to report the clinical and clinicopathological findings in horses with histological changes compatible with IBD in the duodenum. Further, the clinical progression of IBD and survival were investigated. Patient records were reviewed for horses in which histological evidence of IBD was found in duodenal biopsies collected during endoscopy. The histological changes were classified as mild, moderate or severe and the predominant infiltrating cell type was recorded. Clinical improvement was assessed by the owner via a questionnaire at 6 weeks after biopsy, along with survival after one year. In total, 149 horses were included, and the most common clinical signs were weight loss, reduced performance and pain during abdominal palpation. Most horses showed partial malabsorption during an oral glucose absorption test, and the horses with severe IBD had lower serum protein concentrations. Lymphoplasmacytic enteritis was the most common type of IBD (78.5% of cases), while in six horses neutrophilic infiltration of the duodenum was present. Overall, 71% of the cases had improved clinically after six weeks, mostly following treatment with corticosteroids. The results of a second biopsy were a poor predictor of improvement, and the horses that improved after 6 weeks were more likely to be alive after one year.
摘要：
炎症性肠病（IBD）是一种慢性疾病，其特征是肠道中不同的细胞浸润。这项研究的目的是报告具有与十二指肠IBD相容的组织学变化的马的临床和临床病理发现。Further,研究了IBD的临床进展和生存率.回顾了在内窥镜检查期间收集的十二指肠活检中发现IBD组织学证据的马的患者记录。组织学改变被归类为轻度，记录中度或重度和主要浸润细胞类型.活检后6周，患者通过问卷调查评估临床改善情况，以及一年后的生存。总的来说,包括149匹马，最常见的临床症状是体重减轻，腹部触诊时表现和疼痛降低。大多数马在口服葡萄糖吸收试验中表现出部分吸收不良，严重IBD的马血清蛋白浓度较低。淋巴浆细胞性肠炎是最常见的IBD类型(78.5%),而在六匹马中，十二指肠存在嗜中性浸润。总的来说,71％的病例在六周后临床上有所改善，主要是皮质类固醇治疗。第二次活检的结果是改善的不良预测指标，6周后改善的马更有可能在一年后存活。
