PDF(Pubmed)
Abstract：
Natural plants contain numerous chemical compounds that are beneficial to human health. The berries from the Lycium genus are widely consumed and are highly nutritious. Moreover, their chemical constituents have attracted attention for their health-promoting properties. In East Asia, there are three varieties of the Lycium genus (Lycium barbarum L., Lycium chinense Miller, and L. ruthenicum Murray) that possess medicinal value and are commonly used for treating chronic diseases and improving metabolic disorders. These varieties are locally referred to as \"red Goji berries\" or \"black Goji berries\" due to their distinct colors, and they differ in their chemical compositions, primarily in terms of carotenoid and anthocyanin content. The pharmacological functions of these berries include anti-aging, antioxidant, anti-inflammatory, and anti-exercise fatigue effects. This review aims to analyze previous and recent studies on the active ingredients and pharmacological activities of these Lycium varieties, elucidating their signaling pathways and assessing their impact on the gut microbiota. Furthermore, the potential prospects for using these active ingredients in the treatment of COVID-19 are evaluated. This review explores the potential targets of these Lycium varieties in the treatment of relevant diseases, highlighting their potential value in drug development.
摘要：
天然植物含有许多对人体健康有益的化合物。来自枸杞属的浆果被广泛食用并且营养丰富。此外，它们的化学成分因其促进健康的特性而受到关注。在东亚,枸杞属有三个品种（枸杞，枸杞,和L.ruthenicumMurray）具有药用价值，通常用于治疗慢性疾病和改善代谢紊乱。这些品种因其独特的颜色而在当地被称为“红枸杞”或“黑枸杞”，它们的化学成分不同，主要是类胡萝卜素和花青素含量。这些浆果的药理作用包括抗衰老，抗氧化剂，抗炎,和抗运动疲劳效果。本文旨在分析这些枸杞品种的活性成分和药理活性的研究，阐明其信号通路并评估其对肠道微生物群的影响。此外，评估了使用这些活性成分治疗COVID-19的潜在前景。这篇综述探讨了这些枸杞品种在相关疾病治疗中的潜在靶点，强调其在药物开发中的潜在价值。
