PDF(Pubmed)
Abstract：
The future of drug delivery offers immense potential for the creation of nanoplatforms based on nanogels. Nanogels present a significant possibility for pharmaceutical advancements because of their excellent stability and effective drug-loading capability for both hydrophobic and hydrophilic agents. As multifunctional systems, composite nanogels demonstrate the capacity to carry genes, drugs, and diagnostic agents while offering a perfect platform for theranostic multimodal applications. Nanogels can achieve diverse responsiveness and enable the stimuli-responsive release of chemo-/immunotherapy drugs and thus reprogramming cells within the TME in order to inhibit tumor proliferation, progression, and metastasis. In order to achieve active targeting and boost drug accumulation at target sites, particular ligands can be added to nanogels to improve the therapeutic outcomes and enhance the precision of cancer therapy. Modern \"immune-specific\" nanogels also have extra sophisticated tumor tissue-editing properties. Consequently, the introduction of a multifunctional nanogel-based drug delivery system improves the targeted distribution of immunotherapy drugs and combinational therapeutic treatments, thereby increasing the effectiveness of tumor therapy.
摘要：
药物递送的未来为基于纳米凝胶的纳米平台的创建提供了巨大的潜力。纳米凝胶由于其优异的稳定性和对于疏水性和亲水性试剂的有效药物装载能力而呈现药物进步的显著可能性。作为多功能系统，复合纳米凝胶展示了携带基因的能力，毒品,和诊断代理，同时为theranostic多模态应用提供完美的平台。纳米凝胶可以实现不同的反应性，并使化疗/免疫治疗药物的刺激响应性释放，从而在TME内重新编程细胞，以抑制肿瘤增殖。programming,和转移。为了实现主动靶向和促进药物在靶位点的积累，可以将特定的配体添加到纳米凝胶中以改善治疗结果并提高癌症治疗的精确度。现代“免疫特异性”纳米凝胶还具有非常复杂的肿瘤组织编辑特性。因此,基于多功能纳米凝胶的药物递送系统的引入改善了免疫治疗药物和组合治疗治疗的靶向分布，从而提高肿瘤治疗的有效性。
