PDF(Pubmed)
Abstract：
Curcumin, a hydrophobic polyphenol extracted from the rhizome of Curcuma longa, is now considered a candidate drug for the treatment of neurological diseases, including Parkinson\'s Disease (PD), Alzheimer\'s Disease (AD), Huntington\'s Disease (HD), Multiple Sclerosis (MS), Amyotrophic Lateral Sclerosis (ALS), and prion disease, due to its potent anti-inflammatory, antioxidant potential, anticancerous, immunomodulatory, neuroprotective, antiproliferative, and antibacterial activities. Traditionally, curcumin has been used for medicinal and dietary purposes in Asia, India, and China. However, low water solubility, poor stability in the blood, high rate of metabolism, limited bioavailability, and little capability to cross the blood-brain barrier (BBB) have limited the clinical application of curcumin, despite the important pharmacological activities of this drug. A variety of nanocarriers, including liposomes, micelles, dendrimers, cubosome nanoparticles, polymer nanoparticles, and solid lipid nanoparticles have been developed with great success to effectively deliver the active drug to brain cells. Functionalization on the surface of nanoparticles with brain-specific ligands makes them target-specific, which should significantly improve bioavailability and reduce harmful effects. The aim of this review is to summarize the studies on curcumin and/or nanoparticles containing curcumin in the most common neurodegenerative diseases, highlighting the high neuroprotective potential of this nutraceutical.
摘要：
姜黄素,从姜黄根茎中提取的疏水性多酚，现在被认为是治疗神经系统疾病的候选药物，包括帕金森病（PD），阿尔茨海默病（AD），亨廷顿病（HD），多发性硬化(MS),肌萎缩侧索硬化(ALS),和朊病毒病，由于其有效的抗炎作用，抗氧化潜力，抗癌，免疫调节,神经保护,抗增殖,和抗菌活性。传统上,姜黄素已在亚洲用于医疗和饮食目的，印度,和中国。然而,低水溶性，血液稳定性差，高代谢率，有限的生物利用度，和通过血脑屏障（BBB）的能力很少限制了姜黄素的临床应用，尽管这种药物具有重要的药理活性。各种各样的纳米载体，包括脂质体,胶束，树枝状聚合物,立方体纳米粒子，聚合物纳米颗粒，和固体脂质纳米粒已经成功地开发了有效地将活性药物递送到脑细胞。脑特异性配体在纳米颗粒表面上的功能化使它们具有靶特异性，这应该显着提高生物利用度并减少有害影响。本文的目的是总结姜黄素和/或含姜黄素的纳米颗粒在最常见的神经退行性疾病中的研究。突出了这种营养食品的高神经保护潜力。
