PDF(Pubmed)
Abstract：
BACKGROUND: The current study sought to investigate the correlation between vitamin D supplementation in pregnant women with vitamin D deficiency in early pregnancy and the incidence of prenatal depression prior to delivery.
METHODS: This is a retrospective, single-center study that was conducted at a tertiary hospital in Chengdu, China. We conducted an analysis on pregnant women who were initially diagnosed with vitamin D deficiency at 12-14 weeks of gestation. After starting vitamin D supplementation at a dose of 800 IU daily from 14 weeks onwards, we measured both their vitamin D concentration and depression scores again during median gestational week 39 prior to delivery.
RESULTS: The study cohort comprised 1365 women who had been diagnosed with vitamin D deficiency at 12-14 weeks of gestation between November 1st, 2021 to November 1st, 2022. 537 pairs were matched based on a propensity score to control for other confounding factors. After propensity score matching, the baseline vitamin D levels were made consistent between the groups (P = 0.512). The incidence of depression in patients in vitamin D deficiency group following vitamin D supplementation was significantly higher than insufficiency group and reached statistical significance (P < 0.001). Additionally, we observed that serum 25-(OH) D concentration achieving insufficiency status after supplementation was 59.12%.
CONCLUSIONS: Our study indicates that daily supplementation of 800IU of vitamin D can improve the depressive symptoms of individuals who are vitamin D deficiency during early pregnancy but achieve vitamin D insufficiency after supplementation during prenatal period.
METHODS: This is a retrospective, single-center study that was conducted at a tertiary hospital in Chengdu, China. We conducted an analysis on pregnant women who were initially diagnosed with vitamin D deficiency at 12-14 weeks of gestation. After starting vitamin D supplementation at a dose of 800 IU daily from 14 weeks onwards, we measured both their vitamin D concentration and depression scores again during median gestational week 39 prior to delivery.
RESULTS: The study cohort comprised 1365 women who had been diagnosed with vitamin D deficiency at 12-14 weeks of gestation between November 1st, 2021 to November 1st, 2022. 537 pairs were matched based on a propensity score to control for other confounding factors. After propensity score matching, the baseline vitamin D levels were made consistent between the groups (P = 0.512). The incidence of depression in patients in vitamin D deficiency group following vitamin D supplementation was significantly higher than insufficiency group and reached statistical significance (P < 0.001). Additionally, we observed that serum 25-(OH) D concentration achieving insufficiency status after supplementation was 59.12%.
CONCLUSIONS: Our study indicates that daily supplementation of 800IU of vitamin D can improve the depressive symptoms of individuals who are vitamin D deficiency during early pregnancy but achieve vitamin D insufficiency after supplementation during prenatal period.
摘要：
背景：本研究试图调查妊娠早期维生素D缺乏孕妇补充维生素D与分娩前产前抑郁发生率之间的相关性。
方法：这是一个回顾性研究，在成都一家三级医院进行的单中心研究，中国。我们对妊娠12-14周最初诊断为维生素D缺乏的孕妇进行了分析。从14周开始每天以800IU的剂量开始补充维生素D后，我们在分娩前第39周的中位妊娠期间再次测量了他们的维生素D浓度和抑郁评分.
结果：研究队列包括1365名在11月1日妊娠12-14周时被诊断为维生素D缺乏的女性，2021年至11月1日2022年。基于控制其他混杂因素的倾向评分，对537对进行了匹配。在倾向得分匹配后，两组间基线维生素D水平一致(P=0.512).维生素D缺乏组患者补充维生素D后抑郁发生率明显高于不足组,差异有统计学意义(P<0.001)。此外,我们观察到补充后达到功能不全状态的血清25-(OH)D浓度为59.12%。
结论：我们的研究表明，每日补充800IU维生素D可以改善妊娠早期维生素D缺乏但在产前补充维生素D不足的个体的抑郁症状。
方法：这是一个回顾性研究，在成都一家三级医院进行的单中心研究，中国。我们对妊娠12-14周最初诊断为维生素D缺乏的孕妇进行了分析。从14周开始每天以800IU的剂量开始补充维生素D后，我们在分娩前第39周的中位妊娠期间再次测量了他们的维生素D浓度和抑郁评分.
结果：研究队列包括1365名在11月1日妊娠12-14周时被诊断为维生素D缺乏的女性，2021年至11月1日2022年。基于控制其他混杂因素的倾向评分，对537对进行了匹配。在倾向得分匹配后，两组间基线维生素D水平一致(P=0.512).维生素D缺乏组患者补充维生素D后抑郁发生率明显高于不足组,差异有统计学意义(P<0.001)。此外,我们观察到补充后达到功能不全状态的血清25-(OH)D浓度为59.12%。
结论：我们的研究表明，每日补充800IU维生素D可以改善妊娠早期维生素D缺乏但在产前补充维生素D不足的个体的抑郁症状。
