Abstract：
The levels of endothelins were assessed in menopausal women with arterial hypertension (AH) and type 2 diabetes mellitus (T2DM) in the acute phase of the moderate COVID-19. Women under observation (age 45-69 years) were divided into two groups. Control group consisted of women (n=16) who did not have COVID-19, were not vaccinated, and had no antibodies to SARS-CoV-2 (IgG). The main group included women (n=63) in the acute phase of the moderate COVID-19 accompanied by pneumonia. According to the clinical and anamnestic data analysis, the main group was divided into subgroups: without AH and T2DM (n=21); with AH and without T2DM (n=32); and with AH and T2DM (n=10). The parameters of clinical blood analysis, as well as endothelin-1, endothelin-2, and endothelin-3 levels were assessed. In women with a moderate COVID-19, the endothelin-1 and endothelin-2 levels were increased compared to the control regardless of AH and T2DM status. We found no statistically significant differences in the studied parameters of endothelial dysfunction between the subgroups of menopausal women in the acute phase of the moderate COVID-19.
摘要：
在中度COVID-19的急性期，评估了患有动脉高血压（AH）和2型糖尿病（T2DM）的绝经妇女的内皮素水平。将接受观察的妇女（年龄45-69岁）分为两组。对照组由未接种COVID-19、未接种疫苗的女性(n=16)组成，并且没有针对SARS-CoV-2（IgG）的抗体。主要人群包括处于中度COVID-19急性期并伴有肺炎的女性（n=63）。根据临床和记忆障碍数据分析，主要人群分为亚组:无AH和T2DM(n=21);有AH和无T2DM(n=32);AH和T2DM(n=10).临床血液分析的参数，以及内皮素-1,内皮素-2和内皮素-3的水平进行了评估.在中度COVID-19的女性中，与对照组相比，内皮素-1和内皮素-2水平升高，无论AH和T2DM状态如何。我们发现，在中度COVID-19急性期，更年期妇女亚组之间的内皮功能障碍研究参数没有统计学上的显着差异。
