Abstract：
The allele and genotype frequencies of the polymorphic loci CYP1A1 (rs1048943), GSTP1 (rs1695 and rs1138272), GSTM1, and GSTT1 genes were studied in 517 men: in 389 accumulated mercury pollution liquidators (207 firefighters of the Ministry of the Russian Federation for Civil Defence, Emergencies and Elimination of Consequences of Natural Disasters and 182 employees of the Federal Environmental Operator) and 128 former workers (82 patients in the delayed period of chronic mercury intoxication and 46 individuals contacted with mercury and had no chronic mercury intoxication). We found differences in the frequencies of AA and AG genotypes in groups of former workers (χ2=6.96, p=0.008) for the polymorphic locus rs1048943, while the AG-CYP1A1 genotype was characterized by a 5.5-fold decrease in the odds ratio for the development of chronic mercury intoxication (OR=0.18, p=0.0041). An unfavorable combination of genotypes of the studied polymorphic loci increases the risk of undesirable health effects.
摘要：
多态性位点CYP1A1（rs1048943）的等位基因和基因型频率，GSTP1（rs1695和rs1138272），在517名男性中研究了GSTM1和GSTT1基因：在389名累积的汞污染清算人中（俄罗斯联邦民防部的207名消防员，紧急情况和消除自然灾害的后果以及联邦环境运营商的182名雇员）和128名前工人（82名处于慢性汞中毒延迟期的患者和46名接触汞并且没有慢性汞中毒的人）。我们发现，多态性位点rs1048943的前工人群体中AA和AG基因型的频率存在差异（χ2=6.96，p=0.008），而AG-CYP1A1基因型的特征是发展慢性汞中毒的比值比降低了5.5倍（OR=0.18，p=0.0041）。研究的多态性基因座的基因型的不利组合增加了不良健康影响的风险。
