Abstract：
OBJECTIVE: Baghdadite (Ca3ZrSi2O9) cements of various composition have been investigated in this study regarding an application as endodontic filling materials.
METHODS: Cements were either obtained by mixing mechanically activated baghdadite powder with water (maBag) or by subsequently substituting the ß-tricalcium phosphate (ß-TCP) component in a brushite forming calcium phosphate cement. The cements were analyzed for their mechanical performance, injectability, radiopacity, phase composition and antimicrobial properties.
RESULTS: The cements demonstrated sufficient mechanical performance with a compressive strength of ∼1 MPa (maBag) and 2.3 - 17.4 MPa (substituted calcium phosphate cement), good injectability > 80 % depending on the powder to liquid ratio and an intrinsic radiopacity of 1.13 - 2.05 mm aluminum equivalent. Immersion in artificial saliva proved their bioactivity by the formation of calcium phosphate and calcium silicate precipitates on the cement surface. The bacterial activity of Staphylococcus aureus cultured on the surface of the cements was found to be similar compared to clinical standard ProRoot MTA cement or even reduced by a factor of 3 for Streptococcus mutans.
CONCLUSIONS: In combination with their antibacterial properties, baghdadite cements are thought to have the potential to fulfil the clinical requirements for endodontic filling materials.
METHODS: Cements were either obtained by mixing mechanically activated baghdadite powder with water (maBag) or by subsequently substituting the ß-tricalcium phosphate (ß-TCP) component in a brushite forming calcium phosphate cement. The cements were analyzed for their mechanical performance, injectability, radiopacity, phase composition and antimicrobial properties.
RESULTS: The cements demonstrated sufficient mechanical performance with a compressive strength of ∼1 MPa (maBag) and 2.3 - 17.4 MPa (substituted calcium phosphate cement), good injectability > 80 % depending on the powder to liquid ratio and an intrinsic radiopacity of 1.13 - 2.05 mm aluminum equivalent. Immersion in artificial saliva proved their bioactivity by the formation of calcium phosphate and calcium silicate precipitates on the cement surface. The bacterial activity of Staphylococcus aureus cultured on the surface of the cements was found to be similar compared to clinical standard ProRoot MTA cement or even reduced by a factor of 3 for Streptococcus mutans.
CONCLUSIONS: In combination with their antibacterial properties, baghdadite cements are thought to have the potential to fulfil the clinical requirements for endodontic filling materials.
摘要：
目的：本研究中研究了各种组成的Baghdadite（Ca3ZrSi2O9）水泥作为牙髓填充材料的应用。
方法：水泥是通过将机械活化的Baghdadite粉末与水（maBag）混合或随后在透钙磷石形成的磷酸钙水泥中替代β-磷酸三钙（β-TCP）成分而获得的。分析了水泥的力学性能,可注射性,射线不透性,相组成和抗菌性能。
结果：水泥表现出足够的机械性能，抗压强度为〜1MPa（maBag）和2.3-17.4MPa（取代磷酸钙水泥），良好的可注射性>80%,取决于粉末与液体的比率和1.13-2.05mm铝当量的固有射线不透性。通过在水泥表面上形成磷酸钙和硅酸钙沉淀物，浸入人工唾液中证明了其生物活性。发现与临床标准ProRootMTA水泥相比，在水泥表面培养的金黄色葡萄球菌的细菌活性相似，甚至变异链球菌的细菌活性降低了3倍。
结论：结合其抗菌性能，Baghdadite水泥被认为有可能满足牙髓填充材料的临床要求。
方法：水泥是通过将机械活化的Baghdadite粉末与水（maBag）混合或随后在透钙磷石形成的磷酸钙水泥中替代β-磷酸三钙（β-TCP）成分而获得的。分析了水泥的力学性能,可注射性,射线不透性,相组成和抗菌性能。
结果：水泥表现出足够的机械性能，抗压强度为〜1MPa（maBag）和2.3-17.4MPa（取代磷酸钙水泥），良好的可注射性>80%,取决于粉末与液体的比率和1.13-2.05mm铝当量的固有射线不透性。通过在水泥表面上形成磷酸钙和硅酸钙沉淀物，浸入人工唾液中证明了其生物活性。发现与临床标准ProRootMTA水泥相比，在水泥表面培养的金黄色葡萄球菌的细菌活性相似，甚至变异链球菌的细菌活性降低了3倍。
结论：结合其抗菌性能，Baghdadite水泥被认为有可能满足牙髓填充材料的临床要求。
