Abstract：
Hyperlipidemia is not uncommon in patients with hereditary myopathies who get older and also in several conditions in which it is frequently observed. Thus, using the common cholesterol reducing medications of the stains group could be considered. However, the side effects of these drugs include myalgia, myopathy and rhabdomyolysis typically associated with high serum creatine kinase (CK). Because high CK levels are very frequently found in hereditary myopathies, physicians are reluctant to use statins in such patients. Reviewing the literature about statin side effects in hereditary myopathies does not provide a clear evidence about the true risk of these drugs. This review critically describes the reported cases of statin side effects in several genetic myopathies and suggests some guidelines for conditions that are contra indicated for statin usage (particularly in mitochondrial disorders, metabolic myopathies, myotonic dystrophy type 2). Possible solutions to the dilemma of whether to use statins in hereditary myopathies are discussed (prescribing other cholesterol lowering agents and a carefully monitored treatment initiation of statins).
摘要：
高脂血症在变老的遗传性肌病患者以及经常观察到的几种情况下并不少见。因此，可以考虑使用污渍组的常见降胆固醇药物。然而,这些药物的副作用包括肌痛，肌病和横纹肌溶解症通常与高血清肌酸激酶（CK）相关。因为高CK水平在遗传性肌病中很常见，内科医生不愿意在此类患者中使用他汀类药物.回顾有关遗传性肌病中他汀类药物副作用的文献并不能提供有关这些药物真正风险的明确证据。这篇综述严格地描述了几种遗传性肌病中他汀类药物副作用的报道病例，并提出了一些针对他汀类药物使用禁忌条件的指南（特别是在线粒体疾病中，代谢性肌病,强直性肌营养不良2型）。讨论了是否在遗传性肌病中使用他汀类药物的困境的可能解决方案（开具其他降胆固醇药并仔细监测他汀类药物的治疗开始）。
