Abstract：
Chronic wound healing is a major challenge in clinical practice. Secondary dressing damage and antibiotic resistance are the main obstacles for traditional wound dressings. Resina draconis (RD), a natural resin traditionally used in powder form for wound care, is now considered unsuitable due to the lack of gas permeability and moist environment required for wound healing. Here, RD is incorporated in situ by constructing a 3D coiled fibrous scaffold with polycaprolactone/polyethylene oxide. Due to the high porosity of 3D scaffold, the RD-3D dressings have a favorable swelling capacity, providing permeability and moisture for wound repair. Meanwhile, the transformation of RD powder into 3D dressings fully demonstrates capabilities of RD in rapid hemostasis, bactericidal, and inflammation-regulating activities. In vivo evaluations using pressure ulcer and infected wound models confirm the high efficacy of RD-3D dressing in early wound healing, particularly beneficial in the infected wound model compared to recombinant bovine FGF-basic. Further biological analysis shows that resveratrol, loureirin A, and loureirin B, as potentially bioactive components of RD, individually contribute to different aspects of wound healing. Collectively, RD-3D integrated dressings represent a simple, cost-effective, and safe approach to wound healing, providing an alternative therapy for translating medical dressings from bench to bedside.
摘要：
慢性伤口愈合是临床实践中的主要挑战。二次敷料损伤和抗生素抗性是传统伤口敷料的主要障碍。ResinaDraconis（RD），传统上以粉末形式用于伤口护理的天然树脂，由于缺乏气体渗透性和伤口愈合所需的潮湿环境,现在认为是不合适的。这里,我们通过使用聚己内酯（PCL）/聚环氧乙烷（PEO）构建3D盘绕纤维支架来原位结合RD。由于3D支架的高孔隙率，RD-3D敷料具有良好的膨胀能力，为伤口修复提供渗透性和水分。同时,RD粉末向3D敷料的转化充分证明了RD在快速止血中的能力，杀菌和炎症调节活性。使用压疮和感染伤口模型的体内评估证实了RD-3D敷料在早期伤口愈合中的高疗效。与bFGF相比，在感染的伤口模型中特别有益。进一步的生物学分析表明，白藜芦醇，LoureirinA和LoureirinB,作为RD的潜在生物活性成分，个别有助于伤口愈合的不同方面。总的来说，RD-3D集成敷料代表了一个简单的，具有成本效益和安全的伤口愈合方法，提供了一种替代疗法，用于将医用敷料从长凳转移到床边。本文受版权保护。保留所有权利。
