UNASSIGNED: Eighteen children with the FXpm who were identified through cascade testing (89%) or screening at birth (11%) were compared to 21 matched typically developing children, aged 2-4 years. Participants completed standardized assessments of language (Mullen Scales of Early Learning) and adaptive communication (Vineland Adaptive Behavior Scales-II). Social communication was rated from seminaturalistic interaction samples using the Brief Observation of Social Communication Change.
UNASSIGNED: Children with the FXpm showed delayed social communication development, with the magnitude of group differences highlighting social communication as a feature that distinguishes children with the FXpm from their peers (p = .046, ηp2 = .12). The groups did not differ on the standardized language and adaptive communication measures (ps > .297, ηp2s < .03).
UNASSIGNED: Early screening and treatment of social communication delays may be key to optimizing outcomes for children with the FXpm. Further research is needed to replicate findings in a larger sample, delineate the trajectory and consequences of social communication difficulties across the life span in the FXpm, and determine the potential epidemiological significance of FMR1 as a mediator of developmental communication differences within the general population.
■通过级联测试(89%)或出生时筛查(11%)确定的18名FXpm儿童与21名匹配的典型发育儿童进行了比较,2-4岁。参与者完成了语言(早期学习的Mullen量表)和自适应交流(VinelandAdaptiveBehaviorScales-II)的标准化评估。使用《社会传播变化的简要观察》从半自然主义的互动样本中对社会传播进行了评级。
■FXpm的儿童表现出延迟的社会交往发展,群体差异的大小突出了社会交流,这是一个将FXpm儿童与同龄人区分开来的特征(p=.046,ηp2=.12)。两组在标准化语言和适应性沟通措施上没有差异(ps>.297,ηp2s<.03)。
早期筛查和治疗社交延迟可能是优化FXpm儿童预后的关键。需要进一步的研究来复制更大样本中的发现,在FXpm中描绘整个生命周期中社会交往困难的轨迹和后果,并确定FMR1作为一般人群中发育沟通差异的中介者的潜在流行病学意义。