PDF(Pubmed)
Abstract：
UNASSIGNED: This study aimed to assess selenium status in South Korean pregnant women and its impact on maternal thyroid function and pregnancy outcomes.
UNASSIGNED: \'Ideal Breast Milk (IBM) Cohort Study\' included 367 pregnant women out of 442 participants and categorized into three groups based on plasma selenium levels: deficient (< 70 μg/L), suboptimal (70-99 μg/L), and optimal (≥ 100 μg/L). During the second or third trimester, various blood parameters, including selenium, thyroid-stimulating hormone, free T4, free T3, and anti-thyroid peroxidase antibody levels, were measured. Thyroid parenchymal echogenicity was assessed as another surrogate marker for thyroid autoimmunity using ultrasonography.
UNASSIGNED: The median plasma selenium was 98.8 (range: 46.7-206.4) μg/L, and 30 individuals (8%) were categorized as deficient, while 164 (45%) were classified in the suboptimal group. Selenium deficiency was associated with markers of autoimmune thyroiditis, including positive anti-thyroid peroxidase antibody results (13.3 (deficient) vs 4.6 (optimal) %, P = 0.031) and thyroid parenchymal heterogeneity on ultrasound (33.3 (deficient) vs 14.6 (suboptimal) vs 17.3 (optimal) %, P = 0.042), independently of gestational age. The incidence of severe preeclampsia was higher in the group not taking selenium supplements, particularly among those with twin pregnancies, compared to the group taking selenium supplements (0 (selenium supplement) vs 9.0 (no supplement) %, P = 0.015).
UNASSIGNED: Pregnant women experience mild selenium deficiency, which can lead to significant health issues including maternal thyroid autoimmunity and obstetrical complications during pregnancy. Guidelines for appropriate selenium intake according to the stage of pregnancy and the number of fetuses are needed.
UNASSIGNED: \'Ideal Breast Milk (IBM) Cohort Study\' included 367 pregnant women out of 442 participants and categorized into three groups based on plasma selenium levels: deficient (< 70 μg/L), suboptimal (70-99 μg/L), and optimal (≥ 100 μg/L). During the second or third trimester, various blood parameters, including selenium, thyroid-stimulating hormone, free T4, free T3, and anti-thyroid peroxidase antibody levels, were measured. Thyroid parenchymal echogenicity was assessed as another surrogate marker for thyroid autoimmunity using ultrasonography.
UNASSIGNED: The median plasma selenium was 98.8 (range: 46.7-206.4) μg/L, and 30 individuals (8%) were categorized as deficient, while 164 (45%) were classified in the suboptimal group. Selenium deficiency was associated with markers of autoimmune thyroiditis, including positive anti-thyroid peroxidase antibody results (13.3 (deficient) vs 4.6 (optimal) %, P = 0.031) and thyroid parenchymal heterogeneity on ultrasound (33.3 (deficient) vs 14.6 (suboptimal) vs 17.3 (optimal) %, P = 0.042), independently of gestational age. The incidence of severe preeclampsia was higher in the group not taking selenium supplements, particularly among those with twin pregnancies, compared to the group taking selenium supplements (0 (selenium supplement) vs 9.0 (no supplement) %, P = 0.015).
UNASSIGNED: Pregnant women experience mild selenium deficiency, which can lead to significant health issues including maternal thyroid autoimmunity and obstetrical complications during pregnancy. Guidelines for appropriate selenium intake according to the stage of pregnancy and the number of fetuses are needed.
摘要：
目的：本研究旨在评估韩国孕妇的硒状况及其对孕妇甲状腺功能和妊娠结局的影响。
方法：“理想母乳（IBM）队列研究”包括442名参与者中的367名孕妇，并根据血浆硒水平分为三组：缺乏（<70μg/L）。次优(70-99μg/L)，和最佳(≥100μg/L)。在妊娠中期或中期，各种血液参数，包括硒,促甲状腺激素,游离T4、游离T3和抗甲状腺过氧化物酶抗体水平，被测量。使用超声检查评估甲状腺实质回声作为甲状腺自身免疫的另一种替代标志物。
结果：血浆硒中位数为98.8（范围，46.7-206.4)μg/L,和30个人（8％）被归类为缺陷，而164名(45%)被归类为次优组。硒缺乏与自身免疫性甲状腺炎的标志物有关，包括抗甲状腺过氧化物酶抗体阳性结果(13.3[缺乏]vs.4.6[最优]%，P=0.031）和超声检查的甲状腺实质异质性（33.3[缺陷]与14.6[次优]vs.17.3[最佳]%，P=0.042),与胎龄无关。重度子痫前期的发病率在不服用硒补充剂组中较高,尤其是那些双胞胎怀孕的人，与服用硒补充剂组相比(0[硒补充剂]vs.9.0[无补充]%，P=0.015)。
结论：孕妇出现轻度硒缺乏，这可能导致重大的健康问题，包括孕妇甲状腺自身免疫和怀孕期间的产科并发症。需要根据怀孕阶段和胎儿数量适当的硒摄入量指南。
方法：“理想母乳（IBM）队列研究”包括442名参与者中的367名孕妇，并根据血浆硒水平分为三组：缺乏（<70μg/L）。次优(70-99μg/L)，和最佳(≥100μg/L)。在妊娠中期或中期，各种血液参数，包括硒,促甲状腺激素,游离T4、游离T3和抗甲状腺过氧化物酶抗体水平，被测量。使用超声检查评估甲状腺实质回声作为甲状腺自身免疫的另一种替代标志物。
结果：血浆硒中位数为98.8（范围，46.7-206.4)μg/L,和30个人（8％）被归类为缺陷，而164名(45%)被归类为次优组。硒缺乏与自身免疫性甲状腺炎的标志物有关，包括抗甲状腺过氧化物酶抗体阳性结果(13.3[缺乏]vs.4.6[最优]%，P=0.031）和超声检查的甲状腺实质异质性（33.3[缺陷]与14.6[次优]vs.17.3[最佳]%，P=0.042),与胎龄无关。重度子痫前期的发病率在不服用硒补充剂组中较高,尤其是那些双胞胎怀孕的人，与服用硒补充剂组相比(0[硒补充剂]vs.9.0[无补充]%，P=0.015)。
结论：孕妇出现轻度硒缺乏，这可能导致重大的健康问题，包括孕妇甲状腺自身免疫和怀孕期间的产科并发症。需要根据怀孕阶段和胎儿数量适当的硒摄入量指南。
