Abstract：
In positron emission tomography (PET), measurements of depth-of-interaction (DOI) information and time-of-flight (TOF) information are important. DOI information reduces the parallax error, and TOF information reduces noise by measuring the arrival time difference of the annihilation photons. Historically, these have been studied independently, and there has been less implementation of both DOI and TOF capabilities because previous DOI detectors did not have good TOF resolution. However, recent improvements in PET detector performance have resulted in commercial PET scanners achieving a coincidence resolving time of around 200 ps, which result in an effect even for small objects. This means that TOF information can now be utilized even for a brain PET scanner, which also requires DOI information. Therefore, various methods have been proposed to obtain better DOI and TOF information. In addition, the cost of PET detectors is also an important factor to consider, since several hundred detectors are used per PET scanner. In this paper, we review the latest DOI-TOF detectors including the history of detector development. When put into practical use, these DOI-TOF detectors are expected to contribute to the improvement of imaging performance in brain PET scanners.
摘要：
在正电子发射断层扫描(PET)中，相互作用深度(DOI)信息和飞行时间(TOF)信息的测量是重要的。DOI信息减少了视差误差，和TOF信息通过测量湮没光子的到达时间差来降低噪声。历史上,这些都是独立研究的，并且由于以前的DOI检测器没有良好的TOF分辨率，因此DOI和TOF功能的实现较少。然而,PET探测器性能的最新改进导致商用PET扫描仪实现约200ps的重合分辨时间，即使对于小物体也会产生影响。这意味着TOF信息现在甚至可以用于大脑PET扫描仪，这也需要DOI信息。因此,已经提出了各种方法来获得更好的DOI和TOF信息。此外,PET探测器的成本也是需要考虑的重要因素，因为每个PET扫描仪使用几百个探测器。在本文中,我们回顾了最新的DOI-TOF探测器，包括探测器的发展历史。当投入实际使用时，这些DOI-TOF探测器有望有助于改善脑PET扫描仪的成像性能。
