Abstract：
Intracellular pathogens comprise a diverse group of pathogens that all share a required location in a host cell to infect, survive, and replicate. Intracellular location allows pathogens to hide from host immune responses, avoid competition with other pathogens, mediate host cellular functions, replicate safely, and cause infection that is difficult to target with therapeutics. All intracellular pathogens have varying routes of infiltration into host cells and different host cell preferences. For example, bacteria Mycobacterium tuberculosis chooses to invade antigen-presenting cells, which allows them to moderate host antigen presentation to memory cells, whereas rabies virus prefers to invade neurons because they have pre-existing innate immunity protection systems. Regardless of the pathway that each intracellular pathogen follows, all share the capacity to cause disease if they succeed in entering host cells. Here, we give an overview of selected intracellular pathogens and infections they cause, immune responses they induce, and intervention strategies used to treat and control them.
摘要：
细胞内病原体包括一组不同的病原体，它们都在宿主细胞中共享感染所需的位置，生存,和复制。细胞内位置允许病原体躲避宿主的免疫反应，避免与其他病原体竞争，介导宿主细胞功能，安全复制，并导致难以用治疗剂靶向的感染。所有细胞内病原体具有不同的渗入宿主细胞的途径和不同的宿主细胞偏好。例如,结核分枝杆菌选择侵入抗原呈递细胞，这使得它们能够缓和宿主抗原向记忆细胞的呈递，而狂犬病病毒更喜欢侵入神经元，因为它们具有预先存在的先天免疫保护系统。无论每种细胞内病原体遵循的途径如何，如果它们成功进入宿主细胞，它们都具有引起疾病的能力。这里,我们概述了选定的细胞内病原体和它们引起的感染，它们诱导的免疫反应，以及用于治疗和控制它们的干预策略。
