METHODS: Data of patients with IgAN who received TSP or T were retrospectively analyzed. The exclusion criterion was a serum creatinine level > 1.5 mg/dL. The clinical remission and renal survival rates were compared.
RESULTS: Patients were divided into groups based on the treatment method: the TSP (n = 82) and T groups (n = 41). No significant differences were observed in patient characteristics, except for the observation period (TSP: 60 months, T: 113 months). The log-rank test revealed that the clinical remission rate was significantly higher in the TSP group than in the T group (p < 0.05). The superiority of TSP was also observed in the urinary protein excretion (> / = or < 1 g/day) of the two subgroups. According to the Cox proportional-hazards model, the treatment method and daily urinary protein extraction were independent factors affecting clinical remission. The 10-year renal survival rates in the TSP and T groups were 100% and 92.5%, respectively. The log-rank test revealed a tendency for a higher renal survival rate in the TSP group than in the T group (p = 0.09).
CONCLUSIONS: The clinical remission rate was significantly higher with TSP than with T, regardless of urinary protein levels. TSP tended to have a better renal survival rate than T.
方法:回顾性分析接受TSP或T的IgAN患者的数据。排除标准是血清肌酐水平>1.5mg/dL。比较两组患者的临床缓解率和肾脏生存率。
结果:根据治疗方法将患者分为:TSP组(n=82)和T组(n=41)。患者特征没有观察到显著差异,除了观察期(TSP:60个月,T:113个月)。对数秩检验显示,TSP组的临床缓解率明显高于T组(p<0.05)。在两个亚组的尿蛋白排泄(>/=或<1g/天)中也观察到TSP的优越性。根据Cox比例风险模型,治疗方法和每日尿蛋白提取是影响临床缓解的独立因素。TSP组和T组的10年肾脏生存率分别为100%和92.5%,分别。对数秩检验显示,TSP组的肾脏存活率高于T组(p=0.09)。
结论:TSP组临床缓解率明显高于T组,不管尿蛋白水平。TSP往往比T.具有更好的肾脏存活率。