Abstract：
Drug-induced QT prolongation increases the risk of Torsade de Pointes (TdP). Drug-induced QT prolongation is a complex and unpredictable system due to many uncertainties. Risk factors such as electrolyte disturbances, heart failure and genetics play an important role in estimating the effect on QT prolongation. Moreover, the degree of QT prolongation is not always directly related to the risk of TdP and the assessment of the QT-interval is variable depending on the type and timing of QT measurement. Therefore, the variation in QT measurement may be larger than the effect of certain drugs on the QT interval. Because of the potentially lethal risk, several measures are undertaken to reduce the risk of QT prolongation and TdP, while their effect and proportionality are unclear. We suggest we should be less stringent in certain settings when risk of TdP is extremely low given the limited availability of our resources.
摘要：
药物诱导的QT延长会增加尖端扭转（TdP）的风险。由于许多不确定性，药物诱导的QT延长是一个复杂且不可预测的系统。危险因素，如电解质紊乱，心力衰竭和遗传学在评估QT延长的影响中起着重要作用。此外，QT延长的程度并不总是与TdP的风险直接相关,QT间期的评估根据QT测量的类型和时间而变化.因此,QT测量值的变化可能大于某些药物对QT间期的影响.由于潜在的致命风险，采取了几种措施来降低QT延长和TdP的风险，虽然它们的效果和比例尚不清楚。我们建议，鉴于我们的资源有限，当TdP风险极低时，我们应该在某些情况下不那么严格。
