Abstract：
Plakophilin 1 (PKP1) belongs to the desmosome family as an anchoring junction protein in cellular junctions. It localizes at the interface of the cell membrane and cytoplasm. Although PKP1 is a non-transmembrane protein, it may become associated with the cell membrane via transmembrane proteins such as desmocollins and desmogleins. Homozygous deletion of PKP1 results in ectodermal dysplasia-skin fragility syndrome (EDSF) and complete knockout of PKP1 in mice produces comparable symptoms to EDSF in humans, although mice do not survive more than 24 h. PKP1 is not limited to expression in desmosomal structures, but is rather widely expressed in cytoplasm and nucleus, where it assumes important cellular functions. This review will summarize distinct roles of PKP1 in the cell membrane, cytoplasm, and nucleus with an overview of relevant studies on its function in diverse types of cancer.
摘要：
斑蛋白1（PKP1）属于桥粒家族，作为细胞连接中的锚定连接蛋白。它位于细胞膜和细胞质的界面。尽管PKP1是非跨膜蛋白，它可能通过跨膜蛋白如桥粒蛋白和桥粒蛋白与细胞膜结合。PKP1的纯合缺失导致外胚层发育不良-皮肤脆性综合征（EDSF），并且小鼠中PKP1的完全敲除产生与人类EDSF相当的症状。尽管小鼠存活不超过24小时。PKP1不限于在桥粒结构中的表达，但在细胞质和细胞核中广泛表达，它承担着重要的细胞功能。本文将总结PKP1在细胞膜中的不同作用。细胞质，和细胞核，概述了其在各种类型癌症中的功能的相关研究。
