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Abstract：
Spinal cord injury (SCI) represents a complex pathology within the central nervous system (CNS), leading to severe sensory and motor impairments. It activates various signaling pathways, notably the mitogen-activated protein kinase (MAPK) pathway. Present treatment approaches primarily focus on symptomatic relief, lacking efficacy in addressing the underlying pathophysiological mechanisms. Emerging research underscores the significance of the MAPK pathway in neuronal differentiation, growth, survival, axonal regeneration, and inflammatory responses post-SCI. Modulating this pathway post-injury has shown promise in attenuating inflammation, minimizing apoptosis, alleviating neuropathic pain, and fostering neural regeneration. Given its pivotal role, the MAPK pathway emerges as a potential therapeutic target in SCI management. This review synthesizes current knowledge on SCI pathology, delineates the MAPK pathway\'s characteristics, and explores its dual roles in SCI pathology and therapeutic interventions. Furthermore, it addresses the existing challenges in MAPK research in the context of SCI, proposing solutions to overcome these hurdles. Our aim is to offer a comprehensive reference for future research on the MAPK pathway and SCI, laying the groundwork for targeted therapeutic strategies.
摘要：
脊髓损伤（SCI）代表中枢神经系统（CNS）内的复杂病理，导致严重的感觉和运动障碍。它激活各种信号通路，特别是丝裂原活化蛋白激酶（MAPK）途径。目前的治疗方法主要集中在症状缓解，缺乏解决潜在病理生理机制的功效。新兴的研究强调了MAPK通路在神经元分化中的意义，增长,生存,轴突再生,和SCI后的炎症反应。在损伤后调节这一途径已显示出减轻炎症的希望，最小化细胞凋亡，缓解神经性疼痛，促进神经再生。鉴于其关键作用,MAPK通路成为SCI治疗的潜在治疗靶点.这篇综述综合了当前关于SCI病理学的知识，描绘了MAPK通路的特征，并探讨其在SCI病理学和治疗干预中的双重作用。此外，它解决了SCI背景下MAPK研究中的现有挑战，提出了克服这些障碍的解决方案。我们的目的是为未来MAPK通路和SCI的研究提供全面的参考，为有针对性的治疗策略奠定基础。
