PDF(Pubmed)
Abstract：
UNASSIGNED: This case-control study aimed to evaluate calcitonin response in naturally occurring hypercalcemia in cats and assess the relationships between calcitonin and ionized calcium (iCa) and examine relationships between calcitonin, iCa and bone turnover.
UNASSIGNED: Hypercalcemic cats (persistently increased iCa concentration [>1.40 mmol/l]) were identified retrospectively via a medical database search; additional hypercalcemic and normocalcemic cats were recruited prospectively. Data regarding routine biochemical and urine testing, diagnostic imaging and additional blood testing were obtained. Serum alkaline phosphatase (ALP) activity was used as a marker of bone turnover. Serum calcitonin concentration was analyzed using a previously validated immunoradiometric assay. Hypercalcemic cats with an increased calcitonin concentration (>0.9 ng/L) were termed responders. Group comparisons were performed using a Mann-Whitney test for continuous variables and a χ2 test for categorical variables. Spearman\'s correlation coefficient was used to examine the relationships between calcitonin, iCa and ALP.
UNASSIGNED: Twenty-six hypercalcemic and 25 normocalcemic cats were recruited. Only 5/26 (19.2%) of the hypercalcemic cats were identified as responders, and all were diagnosed with idiopathic hypercalcemia. There was no significant correlation between the concentrations of calcitonin and iCa (p = 0.929), calcitonin and ALP (p = 0.917) or iCa and ALP (p = 0.678) in hypercalcemic cats, however, a significant negative correlation was observed between calcitonin and ALP (p = 0.037) when normocalcemic and hypercalcemic cats with an elevated calcitonin concentration were analyzed together.
UNASSIGNED: The expected increase in calcitonin concentration was present in only a small subset of hypercalcemic cats; no correlation was found between iCa and calcitonin concentration. The inverse relationship between calcitonin and ALP in cats with increased calcitonin concentrations suggests that the ability of calcitonin to correct hypercalcemia may be related to the degree of bone turnover.
UNASSIGNED: Hypercalcemic cats (persistently increased iCa concentration [>1.40 mmol/l]) were identified retrospectively via a medical database search; additional hypercalcemic and normocalcemic cats were recruited prospectively. Data regarding routine biochemical and urine testing, diagnostic imaging and additional blood testing were obtained. Serum alkaline phosphatase (ALP) activity was used as a marker of bone turnover. Serum calcitonin concentration was analyzed using a previously validated immunoradiometric assay. Hypercalcemic cats with an increased calcitonin concentration (>0.9 ng/L) were termed responders. Group comparisons were performed using a Mann-Whitney test for continuous variables and a χ2 test for categorical variables. Spearman\'s correlation coefficient was used to examine the relationships between calcitonin, iCa and ALP.
UNASSIGNED: Twenty-six hypercalcemic and 25 normocalcemic cats were recruited. Only 5/26 (19.2%) of the hypercalcemic cats were identified as responders, and all were diagnosed with idiopathic hypercalcemia. There was no significant correlation between the concentrations of calcitonin and iCa (p = 0.929), calcitonin and ALP (p = 0.917) or iCa and ALP (p = 0.678) in hypercalcemic cats, however, a significant negative correlation was observed between calcitonin and ALP (p = 0.037) when normocalcemic and hypercalcemic cats with an elevated calcitonin concentration were analyzed together.
UNASSIGNED: The expected increase in calcitonin concentration was present in only a small subset of hypercalcemic cats; no correlation was found between iCa and calcitonin concentration. The inverse relationship between calcitonin and ALP in cats with increased calcitonin concentrations suggests that the ability of calcitonin to correct hypercalcemia may be related to the degree of bone turnover.
摘要：
■这项病例对照研究旨在评估猫自然发生的高钙血症中的降钙素反应，评估降钙素与离子钙（iCa）之间的关系，并检查降钙素之间的关系。iCa和骨转换。
■通过医学数据库搜索回顾性鉴定了高钙血猫（iCa浓度持续增加[>1.40mmol/l]）；前瞻性招募了其他高钙血猫和正常钙血猫。有关常规生化和尿液检测的数据，获得了诊断成像和额外的血液检测.血清碱性磷酸酶（ALP）活性用作骨转换的标志物。使用先前验证的免疫放射测定法分析血清降钙素浓度。具有增加的降钙素浓度(>0.9ng/L)的高钙血猫被称为反应者。使用连续变量的Mann-Whitney检验和分类变量的χ2检验进行组比较。用Spearman相关系数检验降钙素与降钙素、iCa和ALP。
■招募了26只高血钙猫和25只正常血钙猫。只有5/26（19.2％）的高钙血猫被确定为反应者，所有患者均被诊断为特发性高钙血症。降钙素和iCa的浓度之间没有显着相关性（p=0.929），高钙血猫的降钙素和ALP（p=0.917）或iCa和ALP（p=0.678），然而,当同时分析降钙素浓度升高的正常血钙和高血钙猫时,观察到降钙素和ALP之间存在显著负相关(p=0.037).
■仅在一小部分高钙血猫中存在降钙素浓度的预期增加；在iCa和降钙素浓度之间没有发现相关性。降钙素浓度升高的猫中降钙素和ALP之间的反比关系表明，降钙素纠正高钙血症的能力可能与骨转换程度有关。
■通过医学数据库搜索回顾性鉴定了高钙血猫（iCa浓度持续增加[>1.40mmol/l]）；前瞻性招募了其他高钙血猫和正常钙血猫。有关常规生化和尿液检测的数据，获得了诊断成像和额外的血液检测.血清碱性磷酸酶（ALP）活性用作骨转换的标志物。使用先前验证的免疫放射测定法分析血清降钙素浓度。具有增加的降钙素浓度(>0.9ng/L)的高钙血猫被称为反应者。使用连续变量的Mann-Whitney检验和分类变量的χ2检验进行组比较。用Spearman相关系数检验降钙素与降钙素、iCa和ALP。
■招募了26只高血钙猫和25只正常血钙猫。只有5/26（19.2％）的高钙血猫被确定为反应者，所有患者均被诊断为特发性高钙血症。降钙素和iCa的浓度之间没有显着相关性（p=0.929），高钙血猫的降钙素和ALP（p=0.917）或iCa和ALP（p=0.678），然而,当同时分析降钙素浓度升高的正常血钙和高血钙猫时,观察到降钙素和ALP之间存在显著负相关(p=0.037).
■仅在一小部分高钙血猫中存在降钙素浓度的预期增加；在iCa和降钙素浓度之间没有发现相关性。降钙素浓度升高的猫中降钙素和ALP之间的反比关系表明，降钙素纠正高钙血症的能力可能与骨转换程度有关。
