PDF(Pubmed)
Abstract：
Introduction: Epidemiological evidence over the last few decades has consistently shown that exposure to endocrine-disrupting chemicals (EDCs) is associated with adverse reproductive health outcomes, including male and female infertility, poor-pregnancy outcomes, and increased risk of diseases in childhood and beyond. To investigate the effects of EDCs and lifestyle on all aspects of reproduction (including early oocyte development, fertilization, embryo development, embryo implantation, abortion, and preterm birth). Methods: We performed this cohort study on patients receiving in vitro fertilization (IVF) treatment. Biological samples including urine, serum, follicular fluid, semen, fetal tissue, decidua, and placenta, were obtained. Results: By studying the correlations between reproductive outcomes and environmental pollutant exposure and lifestyle, we determined the toxicological mechanisms and health effects of EDCs on female reproductive health. We found that higher concentrations of per- and polyfluoroalkyl substances were correlated with polycystic ovary syndrome (PCOS). Using specific biomarkers, we also detected the concentrations of organophosphorus flame retardants (OPFRs) in urine and found that OPFRs may disrupt hormone homeostasis. Discussion: All of these results reveal EDCs may disrupt female reproduction.
摘要：
简介：过去几十年的流行病学证据一致表明，暴露于内分泌干扰化学物质（EDC）与不良生殖健康结果有关。包括男性和女性不育，不良妊娠结局，并增加儿童及以后疾病的风险。研究EDC和生活方式对生殖各方面的影响（包括早期卵母细胞发育，受精,胚胎发育,胚胎植入,流产,和早产）。方法：我们对接受体外受精（IVF）治疗的患者进行了队列研究。包括尿液在内的生物样本,血清,卵泡液,精液,胎儿组织,decidua,胎盘,已获得。结果：通过研究生殖结果与环境污染物暴露和生活方式之间的相关性，我们确定了EDC对女性生殖健康的毒理机制和健康影响。我们发现，高浓度的全氟烷基和多氟烷基物质与多囊卵巢综合征（PCOS）有关。使用特定的生物标志物，我们还检测了尿液中有机磷阻燃剂（OPFRs）的浓度，发现OPFRs可能会破坏激素稳态。讨论：所有这些结果表明EDC可能会破坏雌性生殖。
