PDF(Pubmed)
Abstract：
Histoplasmosis is an endemic and invasive mycosis caused by Histoplasma capsulatum. We conducted a retrospective study comparing immunosuppressed patients without human immunodeficiency virus (HIV) with a historical cohort of people with HIV and histoplasmosis. We included 199 patients with proven or probable histoplasmosis, of which 25.1% were people without HIV. Diabetes mellitus, chronic kidney disease, hematologic neoplasms, rheumatologic diseases, and transplantations were more frequent among people without HIV (P < .01). Forty-four percent of immunocompromised patients without HIV died within the first 6-week period following their diagnosis. A high suspicion index for histoplasmosis should be kept in immunosuppressed patients.
摘要：
组织胞浆菌病是由荚膜组织胞浆菌引起的地方性和侵袭性真菌病。我们进行了一项回顾性研究，比较了无人类免疫缺陷病毒（HIV）的免疫抑制患者与HIV和组织胞浆菌病的历史队列。我们纳入了199例确诊或可能的组织胞浆菌病患者，其中25.1%是没有艾滋病毒的人。糖尿病,慢性肾病,血液肿瘤,风湿病,在没有HIV的人群中，移植更为频繁（P<0.01）。44％的无HIV的免疫功能低下患者在诊断后的前6周内死亡。免疫抑制患者应保持对组织胞浆菌病的高度怀疑指数。
