PDF(Pubmed)
Abstract：
This mini-review explores the role of short-chain fatty acids (SCFAs) in posttraumatic stress disorder (PTSD). Highlighting the microbiota-gut-brain axis, this study investigated the bidirectional communication between the gut microbiome and mental health. SCFAs, byproducts of gut microbial fermentation, have been examined for their potential impact on PTSD, with a focus on molecular mechanisms and therapeutic interventions. This review discusses changes in SCFA levels and bacterial profiles in individuals with PTSD, emphasizing the need for further research. Promising outcomes from clinical trials using probiotics and fermented formulations suggest potential avenues for PTSD management. Future directions involve establishing comprehensive human cohorts, integrating multiomics data, and employing advanced computational methods, with the goal of deepening our understanding of the role of SCFAs in PTSD and exploring microbiota-targeted interventions.
摘要：
这篇小型综述探讨了短链脂肪酸（SCFA）在创伤后应激障碍（PTSD）中的作用。突出微生物群-肠-脑轴，这项研究调查了肠道微生物组和心理健康之间的双向交流。SCFA,肠道微生物发酵的副产品，已经检查了它们对创伤后应激障碍的潜在影响，重点关注分子机制和治疗干预措施。这篇综述讨论了PTSD患者SCFA水平和细菌谱的变化，强调需要进一步研究。使用益生菌和发酵制剂的临床试验的有希望的结果提示了PTSD管理的潜在途径。未来的方向涉及建立全面的人类队列，整合多组数据，采用先进的计算方法，目的是加深我们对SCFA在PTSD中的作用的理解，并探索针对微生物群的干预措施。
