PDF(Pubmed)
Abstract：
Anti-beta-2 glycoprotein I antibodies are an important player in hypercoagulable states, including those that lead to antiphospholipid syndrome. Traditionally, assays have only detected IgG and IgM isotypes of this antibody. However, newer assays also detect the IgA isotype. The problem lies in the largely unknown significance of this IgA isotype. This paper describes a middle-aged male who presented with hypertensive emergency and was later found to have IgA anti-beta-2 glycoprotein I antibodies. He was treated with multiple anti-hypertensives, aspirin, and statin therapy. In addition to the case, we discuss the implications of this IgA isotype and how it may relate to antiphospholipid syndrome, despite not currently being included in the laboratory diagnostic criteria for the disease.
摘要：
抗β-2糖蛋白I抗体是高凝状态的重要参与者，包括那些导致抗磷脂综合征的.传统上,分析仅检测到该抗体的IgG和IgM同种型。然而,较新的检测方法也检测IgA同种型。问题在于这种IgA同种型在很大程度上未知的意义。本文描述了一名中年男性，他患有高血压急症，后来被发现患有IgA抗β-2糖蛋白I抗体。他接受了多种抗高血压药的治疗,阿司匹林,和他汀类药物治疗。除了案件,我们讨论了这种IgA同种型的含义以及它与抗磷脂综合征的关系，尽管目前尚未纳入该疾病的实验室诊断标准。
