PDF(Pubmed)
Abstract：
Introduction Periodontitis, a persistent inflammatory condition, impacts the tissues supporting teeth. Beyond mechanically eradicating the biofilm, additional host-modulating agents can aid in the treatment of periodontitis. Among these, gels are a very popular choice for use in the field of dentistry as these systems boast high biocompatibility and bioadhesiveness. These qualities make them easily administered and fabricated. They are typically placed into the periodontal site via wide-port needle syringes. Many investigations have demonstrated that hydrogels possess the ability for controlled drug release and aid in periodontal wound healing. Hence, this study aimed to develop a ferulic acid hydrogel and assess its effectiveness for managing periodontitis. Materials and methods Ferulic acid hydrogel was prepared followed by haemolysis assay and biocompatibility assay. After the in vitro analysis, a clinical trial was conducted: 20 patients were divided into Group A (comprising patients in whom scaling and root planing (SRP) was done) and Group B (comprising patients in whom SRP along with hydrogel application was done). Each patient\'s pocket depth (PD), clinical attachment loss (CAL), gingival index (GI), and plaque index (PI) were recorded at baseline and at three months. Intergroup and intragroup comparisons of the parameters were made. Results Ferulic acid hydrogels exhibit a minimal ratio of red blood cell destruction, indicating their low haemolytic activity. Beyond 94 hours, ferulic acid hydrogel demonstrates minimal toxicity towards human fibroblasts, suggesting it has good biocompatibility. When clinical parameters were compared after three months of treatment with SRP alone, significant reductions were observed in all parameters. However, when hydrogel application was done along with SRP, greater reduction was seen in terms of all clinical parameters indicating the efficacy of the ferulic acid hydrogel as an adjunct. Conclusion Ferulic acid has distinct haemolytic activity as well as good biocompatibility. Its use also led to a considerable reduction in all clinical parameters, necessitating its role as a local drug delivery agent in the treatment of periodontitis.
摘要：
简介牙周炎，持续的炎症,影响支撑牙齿的组织。除了机械根除生物膜，额外的宿主调节剂可以帮助治疗牙周炎。其中,凝胶是牙科领域中使用的非常流行的选择，因为这些系统具有高的生物相容性和生物粘附性。这些品质使它们易于管理和制造。它们通常通过宽端口针注射器放置在牙周部位。许多研究表明，水凝胶具有控制药物释放的能力，并有助于牙周伤口愈合。因此，本研究旨在开发阿魏酸水凝胶并评估其治疗牙周炎的有效性。材料和方法制备阿魏酸水凝胶,然后进行溶血测定和生物相容性测定。经过体外分析,进行了一项临床试验:将20例患者分为A组(包括进行了刮皮和根部平整(SRP)的患者)和B组(包括进行了SRP和水凝胶应用的患者).每位患者的口袋深度（PD），临床附着丧失(CAL)，牙龈指数（GI），在基线和3个月时记录菌斑指数（PI）。进行了组间和组内参数比较。结果阿魏酸水凝胶表现出最小的红细胞破坏率，表明他们的溶血活性低。超过94小时,阿魏酸水凝胶对人类成纤维细胞的毒性最小，表明它具有良好的生物相容性。在单独使用SRP治疗三个月后比较临床参数时，所有参数均显著降低.然而,当水凝胶应用与SRP一起完成时，在所有临床参数方面观察到更大的降低,这表明阿魏酸水凝胶作为助剂的功效.结论阿魏酸具有明显的溶血活性和良好的生物相容性。它的使用也导致了所有临床参数的大幅减少，在牙周炎的治疗中需要其作为局部药物递送剂的作用。
