体外和体内分析显示肿瘤来源的外泌体 miR - 558 通过靶向肝素酶促进舌鳞状细胞癌中的血管生成。
关键词: HPSE angiogenesis exosomes miR-558 tongue squamous cell carcinoma
Mesh : Humans Animals MicroRNAs / genetics Exosomes / metabolism genetics Tongue Neoplasms / pathology genetics metabolism Mice Neovascularization, Pathologic / genetics metabolism pathology Cell Proliferation Cell Movement / genetics Cell Line, Tumor Gene Expression Regulation, Neoplastic Heparin Lyase / metabolism genetics Carcinoma, Squamous Cell / genetics pathology metabolism Human Umbilical Vein Endothelial Cells Disease Models, Animal Xenograft Model Antitumor Assays Squamous Cell Carcinoma of Head and Neck / genetics pathology metabolism Angiogenesis
来 源:
DOI:10.1177/15330338241261615
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