关键词: Idiopathic pulmonary fibrosis Review Signaling pathways

Mesh : Idiopathic Pulmonary Fibrosis / metabolism Humans Signal Transduction / physiology Animals

来  源:   DOI:10.1186/s12931-024-02878-z   PDF(Pubmed)

Abstract:
Idiopathic Pulmonary Fibrosis (IPF) represents a chronic and progressive pulmonary disorder distinguished by a notable mortality rate. Despite the elusive nature of the pathogenic mechanisms, several signaling pathways have been elucidated for their pivotal roles in the progression of this ailment. This manuscript aims to comprehensively review the existing literature on the signaling pathways linked to the pathogenesis of IPF, both within national and international contexts. The objective is to enhance the comprehension of the pathogenic mechanisms underlying IPF and offer a scholarly foundation for the advancement of more efficacious therapeutic strategies, thereby fostering research and clinical practices within this domain.
摘要:
特发性肺纤维化(IPF)代表慢性和进行性肺部疾病,以明显的死亡率为特征。尽管致病机制难以捉摸,已经阐明了几种信号通路在这种疾病的进展中的关键作用。本手稿旨在全面回顾与IPF发病机制相关的信号通路的现有文献。在国家和国际背景下。目的是增强对IPF潜在致病机制的理解,并为更有效的治疗策略的发展提供学术基础。从而促进这一领域的研究和临床实践。
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