Abstract：
OBJECTIVE: The goal of this review is to provide sleep physicians, dentists, and researchers with an evidence-based overview of the literature on smart mandibular advancement devices (MADs) for the treatment of obstructive sleep apnea.
METHODS: A systematic literature search was conducted by two blinded reviewers and an information specialist. A smart MAD was defined as any MAD with additional functionality besides mandibular protrusion. The bibliographic databases Medline, Embase, and Scopus were used to identify relevant publications. Studies were included if they described any stage of development of smart MADs. A total of 3162 titles and abstracts were screened for their relevance. In total, 58 articles were selected for full-text screening, 26 of which were included in this review.
RESULTS: The overall quality of the available literature was low. Most of the studies were observational, clinical or applied-research articles. The authors classified MADs into two main groups: passive and active. Passive MADs measured patient data, most commonly patient compliance. Active MADs adjusted protrusion of the mandible in response to patient data and were found in various phases of technological readiness (in development, demonstration, or deployment).
CONCLUSIONS: Innovations in smart mandibular advancement devices most frequently track patient compliance. Devices measuring other health parameters and active, feedback-controlled, devices are increasingly reported on. However, studies demonstrating their added benefit over traditional methods remain sparse. With further study, smart mandibular advancement devices have the potential to improve the efficiency of obstructive sleep apnea treatment and provide new treatment possibilities.
METHODS: A systematic literature search was conducted by two blinded reviewers and an information specialist. A smart MAD was defined as any MAD with additional functionality besides mandibular protrusion. The bibliographic databases Medline, Embase, and Scopus were used to identify relevant publications. Studies were included if they described any stage of development of smart MADs. A total of 3162 titles and abstracts were screened for their relevance. In total, 58 articles were selected for full-text screening, 26 of which were included in this review.
RESULTS: The overall quality of the available literature was low. Most of the studies were observational, clinical or applied-research articles. The authors classified MADs into two main groups: passive and active. Passive MADs measured patient data, most commonly patient compliance. Active MADs adjusted protrusion of the mandible in response to patient data and were found in various phases of technological readiness (in development, demonstration, or deployment).
CONCLUSIONS: Innovations in smart mandibular advancement devices most frequently track patient compliance. Devices measuring other health parameters and active, feedback-controlled, devices are increasingly reported on. However, studies demonstrating their added benefit over traditional methods remain sparse. With further study, smart mandibular advancement devices have the potential to improve the efficiency of obstructive sleep apnea treatment and provide new treatment possibilities.
摘要：
目的：这篇综述的目的是为睡眠医生提供，牙医,研究人员对智能下颌前移装置（MAD）治疗阻塞性睡眠呼吸暂停的文献进行了循证综述。
方法：由两名盲目性评论者和一名信息专家进行了系统的文献检索。智能MAD被定义为除下颌突出外还具有其他功能的任何MAD。书目数据库Medline，Embase,和Scopus被用来识别相关出版物。如果他们描述了智能MAD的任何发展阶段，则包括研究。总共筛选了3162个标题和摘要的相关性。总的来说,共选取58篇文章进行全文筛选，其中26个被列入本审查。
结果：现有文献的总体质量较低。大多数研究都是观察性的，临床或应用研究文章。作者将MAD分为两大类：被动和主动。被动MAD测量患者数据，最常见的患者依从性。主动MAD根据患者数据调整了下颌骨的突出，并在技术准备的各个阶段（正在开发中，示范,或部署)。
结论：智能下颌前移装置的创新最常跟踪患者的依从性。测量其他健康参数并激活的设备，反馈控制，设备的报道越来越多。然而,证明它们比传统方法有额外好处的研究仍然很少。随着进一步的研究，智能下颌前移装置有可能提高阻塞性睡眠呼吸暂停治疗的效率，并提供新的治疗可能性。
方法：由两名盲目性评论者和一名信息专家进行了系统的文献检索。智能MAD被定义为除下颌突出外还具有其他功能的任何MAD。书目数据库Medline，Embase,和Scopus被用来识别相关出版物。如果他们描述了智能MAD的任何发展阶段，则包括研究。总共筛选了3162个标题和摘要的相关性。总的来说,共选取58篇文章进行全文筛选，其中26个被列入本审查。
结果：现有文献的总体质量较低。大多数研究都是观察性的，临床或应用研究文章。作者将MAD分为两大类：被动和主动。被动MAD测量患者数据，最常见的患者依从性。主动MAD根据患者数据调整了下颌骨的突出，并在技术准备的各个阶段（正在开发中，示范,或部署)。
结论：智能下颌前移装置的创新最常跟踪患者的依从性。测量其他健康参数并激活的设备，反馈控制，设备的报道越来越多。然而,证明它们比传统方法有额外好处的研究仍然很少。随着进一步的研究，智能下颌前移装置有可能提高阻塞性睡眠呼吸暂停治疗的效率，并提供新的治疗可能性。
