Abstract：
Colorectal cancer (CRC) is a common cancer in younger adults. In patients undergoing liver resection with RAS-altered CRCs, there is evidence suggesting younger patients have worse outcomes than older patients. To explain this pattern, differences in associations between RAS status and other cancer-related biomarkers in tumors from younger versus older patients with CRC were evaluated in a cohort of 925 patients with CRC, 277 (30.0%) of whom were ≤50 years old, and 454 (49.1%) who had RAS-altered tumors. For 3 biomarkers, RNF43, APC, and microsatellite instability (MSI), the association with RAS status was significantly modified by age after adjustment for multiple testing. Specifically, younger patients with RAS-altered tumors were more likely to be MSI-high, RNF43 mutated, and APC wild type. These differences might contribute to the observed pattern of diminished survival in younger versus older patients with CRC with RAS-mutated tumors undergoing liver metastasis resection.
摘要：
结直肠癌（CRC）是年轻人中常见的癌症。在接受RAS改变的CRC的肝切除术的患者中，有证据表明年轻患者的预后比老年患者差.为了解释这种模式，在925例CRC患者的队列中评估了年轻和老年CRC患者的RAS状态和其他癌症相关生物标志物之间的相关性差异,277人(30.0%)≤50岁,454人(49.1%)患有RAS改变的肿瘤。对于3种生物标志物，RNF43,APC,和微卫星不稳定性(MSI)，在校正多项测试后,与RAS状态的关联随年龄而显着改变.具体来说,较年轻的RAS改变的肿瘤患者更可能是MSI高，RNF43突变,和APC野生型。这些差异可能有助于观察到年轻与老年CRC患者合并RAS突变肿瘤进行肝转移切除的生存率降低的模式。
