Abstract：
Atherosclerosis, a lipid-driven chronic inflammatory disorder, is a significant global health concern associated with high rates of morbidity and mortality, imposing a substantial societal burden. The purpose of this study is to investigate the possible molecular mechanisms of atherosclerosis and identify potential therapeutic targets. We conducted an integrated bioinformatics analysis using data from peripheral blood mononuclear cell and TISSUE databases obtained from the Gene Expression Omnibus, to identify key genes associated with the progression of atherosclerosis. Here, IRF8 was found to be a key gene in atherosclerosis patients. Silencing IRF8 with small interfering RNA reduced inflammation in endothelial cells. This suggests IRF8 is a crucial biomarker for immune infiltration in atherosclerosis advance.
摘要：
动脉粥样硬化,脂质驱动的慢性炎症性疾病，是与高发病率和死亡率相关的重大全球健康问题，造成巨大的社会负担。本研究的目的是探讨动脉粥样硬化的可能分子机制并确定潜在的治疗靶点。我们使用来自外周血单核细胞和TISSUE数据库的数据进行了综合的生物信息学分析，这些数据来自基因表达综合，确定与动脉粥样硬化进展相关的关键基因。这里,IRF8被发现是动脉粥样硬化患者的关键基因。用小干扰RNA沉默IRF8减少内皮细胞的炎症。这表明IRF8是动脉粥样硬化进展中免疫浸润的关键生物标志物。
