PDF(Pubmed)
Abstract：
BACKGROUND: Oxidative stress is known to affect left ventricular functions negatively. There is a strong bidirectional connection between diabetes mellitus (DM) and oxidative stress. In parallel, left ventricular dysfunction is observed more frequently, even in patients with DM without other risk factors. In this context, the objective of this study is to comparatively investigate the potential relationship between oxidative stress and subclinical left ventricular dysfunction (SCLVD) assessed by Myocardial Performance Index (MPI) in patients with and without DM.
METHODS: The sample of this observational cross-sectional single-center study consisted of 151 patients who were evaluated for oxidative stress and SCLVD by tissue Doppler echocardiography. Patients\' total oxidant status (TOS), total antioxidant status (TAS), and Oxidative Stress Index (OSI) values were calculated. The effects of oxidative stress and DM on MPI were analyzed.
RESULTS: There were 81 patients with DM (mean age: 46.17±10.33 years) and 70 healthy individuals (mean age: 45.72±9.04 years). Mean TOS and OSI values of the DM group were higher than healthy individuals (5.72±0.55 vs 5.31±0.50, p = <0.001; and 4.92±1.93 vs 1.79±0.39, p = <0.001; respectively). The mean TAS value of the DM group was significantly lower than the healthy group (1.21±0.40 vs 3.23±0.51, p = <0.001). There was a significant correlation between OSI and MPI mitral in the DM group (R 0.554, p = <0.001) but not in the healthy group (R -0.069, p=0.249).
CONCLUSIONS: Both oxidative stress and myocardial dysfunction were found to be more common in patients with DM. The study\'s findings indicated the negative effect of oxidative stress on myocardial functions. Accordingly, increased oxidative stress caused more significant deterioration in MPI in patients with DM compared with healthy individuals.
METHODS: The sample of this observational cross-sectional single-center study consisted of 151 patients who were evaluated for oxidative stress and SCLVD by tissue Doppler echocardiography. Patients\' total oxidant status (TOS), total antioxidant status (TAS), and Oxidative Stress Index (OSI) values were calculated. The effects of oxidative stress and DM on MPI were analyzed.
RESULTS: There were 81 patients with DM (mean age: 46.17±10.33 years) and 70 healthy individuals (mean age: 45.72±9.04 years). Mean TOS and OSI values of the DM group were higher than healthy individuals (5.72±0.55 vs 5.31±0.50, p = <0.001; and 4.92±1.93 vs 1.79±0.39, p = <0.001; respectively). The mean TAS value of the DM group was significantly lower than the healthy group (1.21±0.40 vs 3.23±0.51, p = <0.001). There was a significant correlation between OSI and MPI mitral in the DM group (R 0.554, p = <0.001) but not in the healthy group (R -0.069, p=0.249).
CONCLUSIONS: Both oxidative stress and myocardial dysfunction were found to be more common in patients with DM. The study\'s findings indicated the negative effect of oxidative stress on myocardial functions. Accordingly, increased oxidative stress caused more significant deterioration in MPI in patients with DM compared with healthy individuals.
摘要：
背景：已知氧化应激对左心室功能有负面影响。糖尿病（DM）与氧化应激之间存在很强的双向联系。并行,左心室功能障碍更常见，即使在没有其他危险因素的DM患者中。在这种情况下，这项研究的目的是比较研究有和无DM患者的氧化应激与通过心肌功能指数（MPI）评估的亚临床左心室功能障碍（SCLVD）之间的潜在关系。
方法：这项观察性横断面单中心研究的样本包括151名患者，他们通过组织多普勒超声心动图评估了氧化应激和SCLVD。患者总氧化状态（TOS），总抗氧化剂状态（TAS），并计算了氧化应激指数(OSI)值。剖析了氧化应激和DM对MPI的影响。
结果：有81名DM患者（平均年龄：46.17±10.33岁）和70名健康人（平均年龄：45.72±9.04岁）。DM组的平均TOS和OSI值高于健康个体（分别为5.72±0.55vs5.31±0.50，p=<0.001；4.92±1.93vs1.79±0.39，p=<0.001）。DM组的平均TAS值显著低于健康组(1.21±0.40vs3.23±0.51,p=<0.001)。DM组OSI与二尖瓣MPI之间存在显着相关性（R0.554，p=<0.001），而健康组则没有相关性（R-0.069，p=0.249）。
结论：发现氧化应激和心肌功能障碍在DM患者中更为常见。研究结果表明氧化应激对心肌功能有负面影响。因此，与健康个体相比,增加的氧化应激导致DM患者MPI更显著恶化.
方法：这项观察性横断面单中心研究的样本包括151名患者，他们通过组织多普勒超声心动图评估了氧化应激和SCLVD。患者总氧化状态（TOS），总抗氧化剂状态（TAS），并计算了氧化应激指数(OSI)值。剖析了氧化应激和DM对MPI的影响。
结果：有81名DM患者（平均年龄：46.17±10.33岁）和70名健康人（平均年龄：45.72±9.04岁）。DM组的平均TOS和OSI值高于健康个体（分别为5.72±0.55vs5.31±0.50，p=<0.001；4.92±1.93vs1.79±0.39，p=<0.001）。DM组的平均TAS值显著低于健康组(1.21±0.40vs3.23±0.51,p=<0.001)。DM组OSI与二尖瓣MPI之间存在显着相关性（R0.554，p=<0.001），而健康组则没有相关性（R-0.069，p=0.249）。
结论：发现氧化应激和心肌功能障碍在DM患者中更为常见。研究结果表明氧化应激对心肌功能有负面影响。因此，与健康个体相比,增加的氧化应激导致DM患者MPI更显著恶化.
