PDF(Pubmed)
Abstract：
OBJECTIVE: To develop a statistical approach that provides a quantitative index measuring the magnitude of the irregularity of the breathing response to exercise for the diagnosis of dysfunctional breathing.
METHODS: Cross-sectional, retrospective, real-world study.
METHODS: Single-centre study.
METHODS: A population of 209 patients investigated with cardiopulmonary exercise testing in our institution for unexplained or disproportionate exertional dyspnoea between January and July 2022.
METHODS: A novel statistical approach providing a quantitative index-proportional tidal volume variation (PTVV)-was developed to measure the magnitude of the irregularity of the breathing response to exercise.
RESULTS: PTVV provided a reliable statistical readout for the objective assessment of DB with a prediction accuracy of 78% (95% CI: 72 to 83%). The prevalence of DB in the investigated population was high with more than half of the patients affected by moderate-to-severe DB.
CONCLUSIONS: PTVV can easily be implemented in the clinical routine. Our study suggests a possible further simplification for the diagnosis of DB with two objective criteria including PTVV and one single criterion for hyperventilation.
METHODS: Cross-sectional, retrospective, real-world study.
METHODS: Single-centre study.
METHODS: A population of 209 patients investigated with cardiopulmonary exercise testing in our institution for unexplained or disproportionate exertional dyspnoea between January and July 2022.
METHODS: A novel statistical approach providing a quantitative index-proportional tidal volume variation (PTVV)-was developed to measure the magnitude of the irregularity of the breathing response to exercise.
RESULTS: PTVV provided a reliable statistical readout for the objective assessment of DB with a prediction accuracy of 78% (95% CI: 72 to 83%). The prevalence of DB in the investigated population was high with more than half of the patients affected by moderate-to-severe DB.
CONCLUSIONS: PTVV can easily be implemented in the clinical routine. Our study suggests a possible further simplification for the diagnosis of DB with two objective criteria including PTVV and one single criterion for hyperventilation.
摘要：
目的：开发一种统计方法，该方法提供一种定量指标，用于测量对运动的呼吸反应的不规则性，以诊断呼吸功能障碍。
方法：横截面，回顾性,真实世界的研究。
方法：单中心研究。
方法：在2022年1月至7月期间，我们机构对209名患者进行了心肺运动测试，以进行无法解释或不成比例的劳力性呼吸困难。
方法：开发了一种新颖的统计方法，该方法提供了与潮气量变化（PTVV）成比例的定量指标，以测量呼吸对运动的不规则性。
结果：PTVV为DB的客观评估提供了可靠的统计读数，预测准确性为78％（95％CI：72至83％）。在被调查人群中，DB的患病率很高，超过一半的患者受到中度至重度DB的影响。
结论：PTVV可以很容易地在临床常规中实施。我们的研究表明，可以通过两个客观标准（包括PTVV和一个单一的通气过度标准）进一步简化DB的诊断。
方法：横截面，回顾性,真实世界的研究。
方法：单中心研究。
方法：在2022年1月至7月期间，我们机构对209名患者进行了心肺运动测试，以进行无法解释或不成比例的劳力性呼吸困难。
方法：开发了一种新颖的统计方法，该方法提供了与潮气量变化（PTVV）成比例的定量指标，以测量呼吸对运动的不规则性。
结果：PTVV为DB的客观评估提供了可靠的统计读数，预测准确性为78％（95％CI：72至83％）。在被调查人群中，DB的患病率很高，超过一半的患者受到中度至重度DB的影响。
结论：PTVV可以很容易地在临床常规中实施。我们的研究表明，可以通过两个客观标准（包括PTVV和一个单一的通气过度标准）进一步简化DB的诊断。
