Abstract：
BACKGROUND: Quality of life (QOL) and health-related quality of life (HRQOL) in children and adolescents with food allergies have been an important and steadily growing field of research for the past 20 years. There seem to be conceptual and methodological challenges that might influence the face validity of QOL and HRQOL research in general health research, but this has not been investigated in pediatric and adolescent food allergy research up until now. The aim of this study was to perform a systematic review of the QOL and HRQOL studies on food allergy in children and adolescents under the age of 18.
METHODS: The systematic review was conducted on studies purporting to measure QOL or HRQOL in children and adolescents with food allergies. The literature search was developed in Ovid MEDLINE and databases used in the review were Embase, Cochrane Database of Systematic Reviews, CINAHL, and Scopus. Studies were evaluated based on a set of face validity criteria developed by Gill and Feinstein in 1994 and refined by Moons et al. in 2004.
RESULTS: Out of 61 studies eligible for the review, 11 (18%) defined QOL or HRQOL and two distinguished QOL from HRQOL. The Food Allergy Quality of Life (FAQLQ) instrument series is the most frequently used HRQOL measurement among the studies included. QOL and HRQOL were employed interchangeably in half of the studies, some of them also using a third term in addition.
CONCLUSIONS: Our findings lead to the conclusion that the research field investigated contains methodological and conceptual shortcomings regarding QOL and HRQOL. An increased awareness toward the terminology as well as consideration of points to reflect upon will be beneficial, as this will also improve the validity of future studies.
METHODS: The systematic review was conducted on studies purporting to measure QOL or HRQOL in children and adolescents with food allergies. The literature search was developed in Ovid MEDLINE and databases used in the review were Embase, Cochrane Database of Systematic Reviews, CINAHL, and Scopus. Studies were evaluated based on a set of face validity criteria developed by Gill and Feinstein in 1994 and refined by Moons et al. in 2004.
RESULTS: Out of 61 studies eligible for the review, 11 (18%) defined QOL or HRQOL and two distinguished QOL from HRQOL. The Food Allergy Quality of Life (FAQLQ) instrument series is the most frequently used HRQOL measurement among the studies included. QOL and HRQOL were employed interchangeably in half of the studies, some of them also using a third term in addition.
CONCLUSIONS: Our findings lead to the conclusion that the research field investigated contains methodological and conceptual shortcomings regarding QOL and HRQOL. An increased awareness toward the terminology as well as consideration of points to reflect upon will be beneficial, as this will also improve the validity of future studies.
摘要：
背景：在过去的20年中，患有食物过敏的儿童和青少年的生活质量（QOL）和与健康相关的生活质量（HRQOL）一直是重要且稳定增长的研究领域。似乎存在概念和方法上的挑战，可能会影响一般健康研究中QOL和HRQOL研究的表面有效性，但是到目前为止，尚未在儿童和青少年食物过敏研究中进行调查。这项研究的目的是对18岁以下儿童和青少年食物过敏的QOL和HRQOL研究进行系统评价。
方法：对旨在测量食物过敏儿童和青少年QOL或HRQOL的研究进行了系统评价。文献检索是在OvidMEDLINE中开发的，综述中使用的数据库是Embase，Cochrane系统评价数据库，CINAHL,还有Scopus.根据Gill和Feinstein于1994年制定并由Moons等人完善的一组面部有效性标准对研究进行了评估。2004年。
结果：在符合审查条件的61项研究中，11个（18％）定义了QOL或HRQOL，两个人将QOL与HRQOL区分开来。食物过敏生活质量（FAQLQ）仪器系列是包括的研究中最常用的HRQOL测量。QOL和HRQOL在一半的研究中交替使用，其中一些还使用了第三个术语。
结论：我们的研究结果得出的结论是，所调查的研究领域包含有关QOL和HRQOL的方法和概念缺陷。提高对术语的认识以及考虑要反思的要点将是有益的，因为这也将提高未来研究的有效性。
方法：对旨在测量食物过敏儿童和青少年QOL或HRQOL的研究进行了系统评价。文献检索是在OvidMEDLINE中开发的，综述中使用的数据库是Embase，Cochrane系统评价数据库，CINAHL,还有Scopus.根据Gill和Feinstein于1994年制定并由Moons等人完善的一组面部有效性标准对研究进行了评估。2004年。
结果：在符合审查条件的61项研究中，11个（18％）定义了QOL或HRQOL，两个人将QOL与HRQOL区分开来。食物过敏生活质量（FAQLQ）仪器系列是包括的研究中最常用的HRQOL测量。QOL和HRQOL在一半的研究中交替使用，其中一些还使用了第三个术语。
结论：我们的研究结果得出的结论是，所调查的研究领域包含有关QOL和HRQOL的方法和概念缺陷。提高对术语的认识以及考虑要反思的要点将是有益的，因为这也将提高未来研究的有效性。
