Abstract：
Streptococcus suis is a swine bacterial pathogen that predominantly causes disease in weaned piglets characterized by swelling of joints, arthritis, septicemia, meningitis, and sudden death. Intravenous, intramuscular, intraperitoneal, and intranasal infection models were developed to study the bacterial pathogenicity and efficacy of vaccines and various therapeutics. The selection of the appropriate infection model is a critical step in any study, as it may impact the outcomes of the study. Here we describe a method for infecting weaned piglets with S. suis using intraperitoneal route as a reliable, consistent, and reproducible animal model to evaluate vaccine protection against systemic bacterial infection.
摘要：
猪链球菌是一种猪细菌病原体，主要导致断奶仔猪以关节肿胀为特征的疾病，关节炎,败血症,脑膜炎,突然死亡。静脉注射,肌肉内，腹膜内,开发了鼻内感染模型来研究疫苗和各种疗法的细菌致病性和功效。选择合适的感染模型是任何研究的关键步骤,因为它可能会影响研究结果。在这里，我们描述了一种使用腹膜内途径感染猪链球菌的断奶仔猪的方法，一致,和可重复的动物模型，以评估疫苗对全身性细菌感染的保护作用。
