Abstract：
Establishing a biofilm infection model in vivo allows a better understanding of the underlying infection mechanisms of bacteria. Here we describe a method for constructing an in vivo biofilm model of Streptococcus suis. The animal modeled is a piglet, which is the natural reservoir of S. suis, and the mode of clinical infection is simulated by intranasal inoculation of S. suis. This model is in line with clinical practice, easy to operate, and has good repeated stability.
摘要：
在体内建立生物膜感染模型可以更好地了解细菌的潜在感染机制。在这里，我们描述了构建猪链球菌体内生物膜模型的方法。模拟的动物是一头小猪,这是S.Suis的天然水库，通过鼻内接种猪链球菌模拟临床感染模式。该模型符合临床实践，易于操作,具有良好的重复稳定性。
