Abstract：
Red yeast rice has been used to produce alcoholic beverages and various fermented foods especially in East Asia. Since around March 2024, there have been many cases of kidney dysfunction in people who have taken certain supplements containing red yeast rice in Japan. We experienced a case of acute kidney injuries induced after taking a supplement containing red yeast rice. A 58-year-old woman was admitted to our hospital due to renal dysfunction suspected to be caused by taking the supplement Benikoji CholesteHelp®, which contains red yeast rice. With elevations of urinary tubular injury markers such as urinary β2-microglobulin and N-acetyl-β-D-glucosaminidase, serum creatinine levels were elevated up to 2.75 mg/dL. A kidney biopsy revealed a diagnosis of tubulointerstitial nephritis with lymphocytic infiltration of the interstitium, tubular atrophy, and interstitial fibrotic changes. After discontinuation of the supplement and initiation of the prednisolone treatment, renal dysfunction rapidly improved. The course of this case suggests tubular damage caused by the supplements containing red yeast rice. For early diagnosis and treatment, it should be noted that even what are regarded as nutritional health supplements can cause renal dysfunction.
摘要：
红曲米已被用于生产酒精饮料和各种发酵食品，特别是在东亚。自2024年3月左右以来，在日本服用某些含有红曲米的补充剂的人出现了许多肾功能障碍的病例。我们经历了一例服用含有红曲米的补充剂后诱发的急性肾损伤。一名58岁的妇女因怀疑是由于服用补充剂BenikojiCholesteHelp®引起的肾功能不全而入院。其中含有红曲米。随着尿β2-微球蛋白和N-乙酰-β-D-氨基葡萄糖苷酶等尿肾小管损伤标志物的升高，血清肌酐水平升高至2.75mg/dL。肾活检显示肾小管间质性肾炎伴间质淋巴细胞浸润，肾小管萎缩,和间质纤维化改变。终止补充并开始泼尼松龙治疗后，肾功能障碍迅速改善。这种情况的过程表明由含有红曲米的补充剂引起的管状损伤。为了早期诊断和治疗，应该注意的是，即使被认为是营养健康补充剂也会导致肾功能障碍。
