METHODS: In total, 430 cluster headache patients well-characterized according to current International Classification of Headache Disorders criteria, who were all participants in a prior transition-study, were re-interviewed in an observational, retrospective, cross-sectional follow-up study design at the Danish Headache Center.
RESULTS: The transition rate for the whole cohort was 6.5% within one year and 19.8% within five years. The risk of becoming chronic if episodic was 4.0% within one year and 12.3% within five years. For conversion from chronic to episodic, the corresponding risk was 11.1% and 25.0%, respectively. Alterations in attack-side were reported in 32% of all chronic patients, generating an odds ratio of 2.24 of being chronic as opposed to episodic if experiencing side-shifting attacks.
CONCLUSIONS: A higher transition rate since the original cross-sectional study demonstrates cluster headache as a non-static condition. Identifying a risk of transition within one and five years, based on current phenotype along with high odds of being chronic when experiencing a shift of attack-side, offers a valuable clinical compass in the dialogue with the patient.
方法:总共,根据现行国际头痛疾病分类标准,430名丛集性头痛患者特征良好,他们都是先前过渡研究的参与者,在一次观察中被重新采访,回顾性,丹麦头痛中心的横断面随访研究设计。
结果:整个队列的过渡率在一年内为6.5%,在五年内为19.8%。如果发生偶发性,则成为慢性的风险在一年内为4.0%,在五年内为12.3%。从慢性转变为情节,相应的风险为11.1%和25.0%,分别。据报道,在所有慢性患者中,有32%的患者出现了发作侧的改变,如果经历侧移攻击,则产生2.24的慢性优势比,而不是发作性。
结论:自原始横断面研究以来,更高的过渡率表明丛集性头痛是一种非静态疾病。确定在一年和五年内过渡的风险,基于当前的表型以及在经历攻击侧转移时慢性的高几率,在与患者的对话中提供了一个有价值的临床指南针。