Abstract：
ErbB3-binding protein 1(Ebp1) has two isoforms, p42 Ebp1 and p48 Ebp1, both of which can regulate cell growth and differentiation. But these isoforms often have opposite effects, including contradictory roles in regulation of cell growth in different tissues and cells. P48 Ebp1 belongs to the full-length sequence, while conformational changes in the crystal structure of p42 Ebp1 reveals a lack of an α helix at the amino terminus. Due to the differences in the structures of these two isoforms, they have different binding partners and protein modifications. Ebp1 can function as both an oncogene and a tumor suppressor factor. However, the underlying mechanisms by which these two isoforms exert opposite functions are still not fully understood. In this review, we summarize the genes and the structures of protein of these two isoforms, protein modifications, binding partners and the association of different isoforms with diseases.
摘要：
ErbB3结合蛋白1（Ebp1）有两个亚型，p42Ebp1和p48Ebp1均能调控细胞的生长和分化。但是这些同工型通常有相反的作用，包括在不同组织和细胞中调节细胞生长的矛盾作用。P48Ebp1属于全长序列，而p42Ebp1晶体结构的构象变化表明在氨基末端缺乏α螺旋。由于这两种同工型结构的差异,它们具有不同的结合伴侣和蛋白质修饰。Ebp1既可以作为癌基因又可以作为肿瘤抑制因子。然而,这两种同工型发挥相反功能的潜在机制仍未完全理解。在这次审查中,我们总结了这两种亚型的基因和蛋白质结构，蛋白质修饰，结合伴侣和不同同工型与疾病的关联。
