PDF(Pubmed)
Abstract：
Middle ear neuroendocrine tumor (MeNET) is a low-grade tumor with rare recurrence or metastasis. Here, we describe the case of a 29-year-old man who suffered from MeNET that recurred 3 times over 10 years and eventually metastasized to the brain. The patient was treated with surgical resection, radiotherapy, and chemotherapy. However, the tumor was not entirely removed as the brain metastatic tumor adhered tightly to the brainstem. Due to tumor rupture and bleeding after multiple brain tumor removal, profound coma developed. Finally, the patient died 10 months after the last surgery. To our knowledge, this is the first report of a MeNET case with multiple brain metastases. Characteristics of the present case indicate that CK, SYN, increased Ki67 index, and ATRX may be potential biomarkers of invasive MeNET. The survival of patients with brain metastatic MeNET may be extended by surgical resection, radiotherapy, and chemotherapy. Close follow-up of distinctive metastases and biomarkers related to recurrence is also suggested.
摘要：
中耳神经内分泌肿瘤(MeNET)是一种少见复发或转移的低度恶性肿瘤。这里,我们描述了一个29岁的男性，他患有MeNET，在10年内复发了3次，最终转移到大脑。病人接受了手术切除治疗,放射治疗,和化疗。然而,由于脑转移瘤紧密粘附在脑干上,肿瘤未完全切除.由于多发脑肿瘤切除后肿瘤破裂出血，严重的昏迷发展。最后,患者在最后一次手术后10个月死亡。据我们所知,这是一例MeNET多发性脑转移病例的首次报道。本案的特点表明，CK，SYN,增加了Ki67指数，ATRX可能是侵袭性MeNET的潜在生物标志物。脑转移性MeNET患者的生存期可以通过手术切除来延长，放射治疗,和化疗。还建议密切随访与复发相关的独特转移和生物标志物。
