PDF(Pubmed)
Abstract：
UNASSIGNED: The objective of this study was to assess reproductive outcomes of D6 blastocysts transferred on day 6 in comparison to those transferred on day 7 of progesterone exposure in frozen-thawed embryo transfer cycles.
UNASSIGNED: This retrospective cohort study included 2029 D6 single blastocysts from the first frozen-thawed embryo transfer cycles of patients at the Hospital for Reproductive Medicine Affiliated to Shandong University from February 2017 to January 2020. Participants were divided into Group A (blastocyst transferred on the 6th day of progesterone exposure, n=1634) and Group B (blastocyst transferred on the 7th day of progesterone exposure, n=395).
UNASSIGNED: The live birth rate was comparable between Group A and Group B (38.7% versus 38.7%, P=0.999). Subgroup analysis revealed a significantly higher preterm birth rate in D6 single blastocysts transferred on the 7th day than in those transferred on the 6th day of progesterone exposure for natural cycle frozen-thawed embryo transfer (5.2% versus 11.3%, P=0.020). After adjustment for potential confounders, the differences in the preterm birth rate in natural cycles persisted (adjusted odds ratio 2.347, 95% confidence interval 1.129-4.877, P=0.022).
UNASSIGNED: In frozen-thawed embryo transfer cycles, transferring on the 6th or 7th day of progesterone exposure of D6 blastocysts did not affect the live birth rate; however, when a natural cycle protocol is adopted, the possible preterm risk of transferring D6 blastocysts on the 7th day of progesterone exposure should be noted.
UNASSIGNED: This retrospective cohort study included 2029 D6 single blastocysts from the first frozen-thawed embryo transfer cycles of patients at the Hospital for Reproductive Medicine Affiliated to Shandong University from February 2017 to January 2020. Participants were divided into Group A (blastocyst transferred on the 6th day of progesterone exposure, n=1634) and Group B (blastocyst transferred on the 7th day of progesterone exposure, n=395).
UNASSIGNED: The live birth rate was comparable between Group A and Group B (38.7% versus 38.7%, P=0.999). Subgroup analysis revealed a significantly higher preterm birth rate in D6 single blastocysts transferred on the 7th day than in those transferred on the 6th day of progesterone exposure for natural cycle frozen-thawed embryo transfer (5.2% versus 11.3%, P=0.020). After adjustment for potential confounders, the differences in the preterm birth rate in natural cycles persisted (adjusted odds ratio 2.347, 95% confidence interval 1.129-4.877, P=0.022).
UNASSIGNED: In frozen-thawed embryo transfer cycles, transferring on the 6th or 7th day of progesterone exposure of D6 blastocysts did not affect the live birth rate; however, when a natural cycle protocol is adopted, the possible preterm risk of transferring D6 blastocysts on the 7th day of progesterone exposure should be noted.
摘要：
本研究的目的是评估在冻融胚胎移植周期中与孕酮暴露第7天移植的D6胚泡的生殖结果。
这项回顾性队列研究包括2017年2月至2020年1月在山东大学附属生殖医学医院进行的首次冻融胚胎移植周期的2029个D6单个囊胚。参与者分为A组（孕酮暴露的第6天移植的胚泡，n=1634）和B组（孕酮暴露的第7天移植的胚泡，n=395）。
■A组和B组的活产率相当（38.7％对38.7％，P=0.999)。亚组分析显示，与孕酮暴露于自然周期冻融胚胎移植的第6天相比，第7天移植的D6单个囊胚的早产率明显更高（5.2％对11.3％，P=0.020)。在调整了潜在的混杂因素后，自然周期中早产率的差异持续存在(调整后比值比2.347,95%置信区间1.129-4.877,P=0.022).
■在冻融胚胎移植周期中，在孕酮暴露的第6天或第7天转移D6囊胚并不影响活产率；但是，当采用自然循环协议时，应注意孕酮暴露第7天转移D6囊胚的可能早产风险.
这项回顾性队列研究包括2017年2月至2020年1月在山东大学附属生殖医学医院进行的首次冻融胚胎移植周期的2029个D6单个囊胚。参与者分为A组（孕酮暴露的第6天移植的胚泡，n=1634）和B组（孕酮暴露的第7天移植的胚泡，n=395）。
■A组和B组的活产率相当（38.7％对38.7％，P=0.999)。亚组分析显示，与孕酮暴露于自然周期冻融胚胎移植的第6天相比，第7天移植的D6单个囊胚的早产率明显更高（5.2％对11.3％，P=0.020)。在调整了潜在的混杂因素后，自然周期中早产率的差异持续存在(调整后比值比2.347,95%置信区间1.129-4.877,P=0.022).
■在冻融胚胎移植周期中，在孕酮暴露的第6天或第7天转移D6囊胚并不影响活产率；但是，当采用自然循环协议时，应注意孕酮暴露第7天转移D6囊胚的可能早产风险.
