PDF(Pubmed)
Abstract：
UNASSIGNED: The incidence of oropharyngeal candidiasis among people living with human immunodeficiency virus in Africa is on the rise. Oropharyngeal candidiasis is mainly caused by C.albicans; however, a shift in the etiology towards non-Candida albicans species is increasing. In addition, there are variations in the epidemiological distribution of Candida species causing oropharyngeal candidiasis among people living with human immunodeficiency virus in Africa.
UNASSIGNED: This review aimed to determine the prevalence of oropharyngeal candidiasis and the distribution of Candida species among people living with human immunodeficiency virus in Africa.
UNASSIGNED: This systematic review protocol was registered in the base PROSPERO database prior to its conduct (CRD42021254473). The Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocol guidelines (PRISMA-P) were followed for this study. The PubMed, Scopus and EMBASE databases were searched to identify published studies published between 1st January 2000 and 8th October 2022. The eligible studies were included in the meta-analysis and analyzed using a random effects model. The risk of bias of the included studies was assessed using the Joanna Briggs Institute quality assessment tool for prevalence studies.
UNASSIGNED: The database search yielded 370 titles from PubMed (n=192), EMBASE (n=162) and SCOPUS (n=16). Fourteen studies with a total of 3,863 participants were included in the meta-analysis. The pooled prevalence of oropharyngeal candidiasis was 49.0% (95% CI: 37% - 62%). A total of 2,688 Candida isolates were reported; approximately 76.6% (n=2,060) were C. albicans, and 21.7% (n=582) were non-C. albicans. Among the non-Candida albicans species, C. glabrata was the most common isolate (29.6%), followed by C. tropicalis (27.7%), C. krusei (17.0%), C. parapsilosis (8.1%) and C. dubliniensis (5.2%). Out of 14 studies, 7 (50.0%) had a low risk of bias, 5 (35.7%) had a moderate risk of bias, and 2 (14.3%) had a high risk of bias.
UNASSIGNED: Almost half of people living with HIV in Africa have oropharyngeal candidiasis, and C. albicans remains the most frequent cause of oropharyngeal candidiasis.
UNASSIGNED: This review aimed to determine the prevalence of oropharyngeal candidiasis and the distribution of Candida species among people living with human immunodeficiency virus in Africa.
UNASSIGNED: This systematic review protocol was registered in the base PROSPERO database prior to its conduct (CRD42021254473). The Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocol guidelines (PRISMA-P) were followed for this study. The PubMed, Scopus and EMBASE databases were searched to identify published studies published between 1st January 2000 and 8th October 2022. The eligible studies were included in the meta-analysis and analyzed using a random effects model. The risk of bias of the included studies was assessed using the Joanna Briggs Institute quality assessment tool for prevalence studies.
UNASSIGNED: The database search yielded 370 titles from PubMed (n=192), EMBASE (n=162) and SCOPUS (n=16). Fourteen studies with a total of 3,863 participants were included in the meta-analysis. The pooled prevalence of oropharyngeal candidiasis was 49.0% (95% CI: 37% - 62%). A total of 2,688 Candida isolates were reported; approximately 76.6% (n=2,060) were C. albicans, and 21.7% (n=582) were non-C. albicans. Among the non-Candida albicans species, C. glabrata was the most common isolate (29.6%), followed by C. tropicalis (27.7%), C. krusei (17.0%), C. parapsilosis (8.1%) and C. dubliniensis (5.2%). Out of 14 studies, 7 (50.0%) had a low risk of bias, 5 (35.7%) had a moderate risk of bias, and 2 (14.3%) had a high risk of bias.
UNASSIGNED: Almost half of people living with HIV in Africa have oropharyngeal candidiasis, and C. albicans remains the most frequent cause of oropharyngeal candidiasis.
摘要：
背景：非洲人类免疫缺陷病毒携带者口咽念珠菌病的发病率呈上升趋势。口咽念珠菌病主要由白色念珠菌引起;然而,病因学向非白色念珠菌物种的转变正在增加。此外,非洲人类免疫缺陷病毒携带者中引起口咽念珠菌病的念珠菌的流行病学分布存在差异.目的：本综述旨在确定非洲人类免疫缺陷病毒携带者口咽念珠菌病的患病率和念珠菌的分布。材料和方法：该系统评价方案在进行之前已在基础PROSPERO数据库中注册（CRD42021254473）。本研究遵循系统评价和荟萃分析方案指南（PRISMA-P）的首选报告项目。PubMed,搜索了Scopus和EMBASE数据库，以确定2000年1月1日至2022年10月8日之间发表的已发表研究。将符合条件的研究纳入荟萃分析，并使用随机效应模型进行分析。使用JoannaBriggs研究所的患病率研究质量评估工具评估纳入研究的偏倚风险。结果：数据库搜索从PubMed获得了370个标题(n=192)，EMBASE(n=162)和SCOPUS(n=16)。14项研究共3,863名参与者被纳入荟萃分析。口咽念珠菌病的合并患病率为49.0％（95％CI：37％-62％）。总共报告了2,688株念珠菌；大约76.6％（n=2,060）是白色念珠菌，21.7%(n=582)为非白色念珠菌。在非白色念珠菌物种中，光滑梭菌是最常见的分离株(29.6%)，其次是热带梭菌(27.7%)，C.克鲁斯伊（17.0%），拟态梭菌(8.1%)和都柏林梭菌(5.2%)。在14项研究中，7人(50.0%)的偏倚风险较低，5（35.7%）有中等偏倚风险，2例(14.3%)存在较高的偏倚风险.结论：非洲几乎一半的艾滋病毒感染者患有口咽念珠菌病，白色念珠菌仍然是口咽念珠菌病的最常见原因。
