PDF(Pubmed)
Abstract：
UNASSIGNED: Metabolic dysfunction-associated steatotic liver disease (MASLD) presents a growing health concern in pediatric populations due to its association with obesity and metabolic syndrome. Bioelectrical impedance analysis (BIA) offers a non-invasive and potentially effective alternative for identifying MASLD risk in youth with overweight or obesity. Therefore, this study aimed to assess the utility of BIA for screening for MASLD in the youth.
UNASSIGNED: This retrospective, cross-sectional study included 206 children and adolescents aged <20 years who were overweight and obese. The correlations between anthropometric measurements and BIA parameters and alanine aminotransferase (ALT) levels were assessed using Pearson\'s correlation analysis. Logistic regression analysis was performed to examine the associations between these parameters and ALT level elevation and MASLD score. Receiver operating characteristic (ROC) curves were generated to assess the predictive ability of the parameters for MASLD.
UNASSIGNED: Pearson\'s correlation analysis revealed that waist-to-hip ratio (WHR), percentage body fat (PBF), and BIA parameters combined with anthropometric measurements were correlated with ALT level. Logistic regression revealed that WHR, skeletal muscle mass/WHR, PBF-WHR, fat-free mass/WHR, and appendicular skeletal muscle mass/WHR were correlated with ALT level elevation after adjusting for age, sex, and puberty. WHR, PBF-WHR, and visceral fat area (VFA)-WHR were positively correlated with the MASLD score in the total population after adjusting for age, sex, and puberty. PBF-WHR and VFA-WHR were correlated with the MASLD score even in youth with a normal ALT level. The cutoff points and area under the ROC curves were 34.6 and 0.69 for PBF-WHR, respectively, and 86.6 and 0.79 for VFA-WHR, respectively.
UNASSIGNED: This study highlights the utility of combining BIA parameters and WHR in identifying the risk of MASLD in overweight and obese youth, even in those with a normal ALT level. BIA-based screening offers a less burdensome and more efficient alternative to conventional MASLD screening methods, facilitating early detection and intervention in youth at risk of MASLD.
UNASSIGNED: This retrospective, cross-sectional study included 206 children and adolescents aged <20 years who were overweight and obese. The correlations between anthropometric measurements and BIA parameters and alanine aminotransferase (ALT) levels were assessed using Pearson\'s correlation analysis. Logistic regression analysis was performed to examine the associations between these parameters and ALT level elevation and MASLD score. Receiver operating characteristic (ROC) curves were generated to assess the predictive ability of the parameters for MASLD.
UNASSIGNED: Pearson\'s correlation analysis revealed that waist-to-hip ratio (WHR), percentage body fat (PBF), and BIA parameters combined with anthropometric measurements were correlated with ALT level. Logistic regression revealed that WHR, skeletal muscle mass/WHR, PBF-WHR, fat-free mass/WHR, and appendicular skeletal muscle mass/WHR were correlated with ALT level elevation after adjusting for age, sex, and puberty. WHR, PBF-WHR, and visceral fat area (VFA)-WHR were positively correlated with the MASLD score in the total population after adjusting for age, sex, and puberty. PBF-WHR and VFA-WHR were correlated with the MASLD score even in youth with a normal ALT level. The cutoff points and area under the ROC curves were 34.6 and 0.69 for PBF-WHR, respectively, and 86.6 and 0.79 for VFA-WHR, respectively.
UNASSIGNED: This study highlights the utility of combining BIA parameters and WHR in identifying the risk of MASLD in overweight and obese youth, even in those with a normal ALT level. BIA-based screening offers a less burdensome and more efficient alternative to conventional MASLD screening methods, facilitating early detection and intervention in youth at risk of MASLD.
摘要：
代谢功能障碍相关的脂肪变性肝病（MASLD）由于与肥胖和代谢综合征有关，在儿科人群中引起了越来越多的健康关注。生物电阻抗分析（BIA）为识别超重或肥胖青年的MASLD风险提供了一种非侵入性且潜在有效的替代方法。因此,本研究旨在评估BIA对青少年MASLD筛查的实用性.
■这次回顾展，横断面研究包括206名超重和肥胖的20岁以下儿童和青少年.使用Pearson相关分析评估人体测量值与BIA参数和丙氨酸氨基转移酶（ALT）水平之间的相关性。进行Logistic回归分析以检查这些参数与ALT水平升高和MASLD评分之间的关联。产生受试者工作特征(ROC)曲线以评估参数对MASLD的预测能力。
■皮尔森的相关分析显示，腰臀比(WHR)，体脂百分比（PBF），BIA参数结合人体测量与ALT水平相关。Logistic回归显示，WHR，骨骼肌质量/WHR，PBF-WHR,无脂质量/WHR，调整年龄后，阑尾骨骼肌质量/WHR与ALT水平升高相关，性别,和青春期。WHR,PBF-WHR,和内脏脂肪面积(VFA)-WHR在调整年龄后与总人群的MASLD评分呈正相关,性别,和青春期。即使在ALT水平正常的年轻人中，PBF-WHR和VFA-WHR也与MASLD评分相关。PBF-WHR的截止点和ROC曲线下面积分别为34.6和0.69，分别,VFA-WHR为86.6和0.79，分别。
■这项研究强调了结合BIA参数和WHR在识别超重和肥胖青少年MASLD风险中的实用性，即使在那些与正常ALT水平。基于BIA的筛选为传统的MASLD筛选方法提供了更少的负担和更有效的替代方法，促进对有MASLD风险的青年的早期发现和干预。
■这次回顾展，横断面研究包括206名超重和肥胖的20岁以下儿童和青少年.使用Pearson相关分析评估人体测量值与BIA参数和丙氨酸氨基转移酶（ALT）水平之间的相关性。进行Logistic回归分析以检查这些参数与ALT水平升高和MASLD评分之间的关联。产生受试者工作特征(ROC)曲线以评估参数对MASLD的预测能力。
■皮尔森的相关分析显示，腰臀比(WHR)，体脂百分比（PBF），BIA参数结合人体测量与ALT水平相关。Logistic回归显示，WHR，骨骼肌质量/WHR，PBF-WHR,无脂质量/WHR，调整年龄后，阑尾骨骼肌质量/WHR与ALT水平升高相关，性别,和青春期。WHR,PBF-WHR,和内脏脂肪面积(VFA)-WHR在调整年龄后与总人群的MASLD评分呈正相关,性别,和青春期。即使在ALT水平正常的年轻人中，PBF-WHR和VFA-WHR也与MASLD评分相关。PBF-WHR的截止点和ROC曲线下面积分别为34.6和0.69，分别,VFA-WHR为86.6和0.79，分别。
■这项研究强调了结合BIA参数和WHR在识别超重和肥胖青少年MASLD风险中的实用性，即使在那些与正常ALT水平。基于BIA的筛选为传统的MASLD筛选方法提供了更少的负担和更有效的替代方法，促进对有MASLD风险的青年的早期发现和干预。
