PDF(Pubmed)
Abstract：
The etiology for concurrent attacks of abdominal pain, nausea, vomiting, and diarrhea can be obscure. Mast cell activation syndrome is not usually considered in this differential diagnosis. A 53-year-old paint salesman suffered severe attacks of these symptoms for the 3 decades of his career. Nortriptyline, loperamide, hyoscyamine, and ondansetron failed to address his symptoms. Mast cell activation syndrome was ultimately diagnosed. Intravenous mast cell-targeted therapy reduced severity of attacks. Multiple oral mast cell-targeted treatments were ineffective, but addition of low-dose imatinib resulted in dramatic improvement. Recognition that paint-fume exposure-triggered attacks led to behavioral modifications which further reduced symptoms.
摘要：
并发腹痛的病因，恶心,呕吐,腹泻可能是模糊的。在这种鉴别诊断中通常不考虑肥大细胞活化综合征。一位53岁的油漆销售员在职业生涯的30年里遭受了这些症状的严重攻击。Nortriptyline,洛哌丁胺,盐酸,昂丹司琼也没能解决他的症状.最终诊断为肥大细胞活化综合征。静脉用肥大细胞靶向治疗可降低发作的严重程度。多次口服肥大细胞靶向治疗无效,但低剂量伊马替尼的加入导致了显著的改善.认识到油漆烟雾暴露引发的攻击会导致行为改变，从而进一步减轻症状。
