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Abstract：
This study aims to investigate the correlation between plasma fat-soluble vitamin levels and blood lipid in elderly patients with coronary heart disease (CHD). A total of 120 participants were enrolled, including 60 CHD patients and 60 controls without CHD. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) was used to quantify plasma levels of vitamins A, D3, E, and K. Data analysis was conducted using the statistical analysis system module of MetaboAnalyst 5.0. The CHD group showed significantly higher levels of plasma total cholesterol (TC), triglycerides (TG), and low-density lipoprotein cholesterol (LDL-C) but not high-density lipoprotein cholesterol (HDL-C) compared to controls. The CHD group exhibited significantly higher plasma levels of VA and VE, positively correlating with TC, TG, and LDL-C. After adjusted by TG levels, the CHD group had significantly lower plasma levels of VA and VE, negatively correlating with TC, TG, and LDL-C. The CHD group also had significantly lower concentrations of VD3, independent of TG modification, compared to controls. VD3 negatively correlated with TC, TG, and LDL-C. Elderly individuals with CHD display abnormal blood lipid metabolism, and fat-soluble vitamins adjusted by TG levels can more accurately and timely response to implicit fat-soluble vitamins deficiency in CHD patients.
摘要：
本研究旨在探讨老年冠心病患者血浆脂溶性维生素水平与血脂的相关性。共有120名参与者报名参加，包括60例CHD患者和60例非CHD对照。液相色谱-串联质谱（LC-MS/MS）用于定量维生素A的血浆水平，D3,E,使用MetaboAnalyst5.0的统计分析系统模块进行数据分析。CHD组血浆总胆固醇(TC)水平明显增高,甘油三酯（TG），与对照组相比，低密度脂蛋白胆固醇（LDL-C）而不是高密度脂蛋白胆固醇（HDL-C）。CHD组血浆VA和VE水平明显增高,与TC呈正相关，TG,和LDL-C经TG水平调整后，冠心病组血浆VA和VE水平显著降低,与TC负相关，TG,和LDL-CCHD组的VD3浓度也明显降低，与TG修饰无关，与对照组相比。VD3与TC呈负相关，TG,和LDL-C老年冠心病患者血脂代谢异常,而脂溶性维生素通过调节TG水平可以更准确、及时地应对冠心病患者的隐性脂溶性维生素缺乏。
