PDF(Pubmed)
Abstract：
Salivary gland tumors are relatively rare and can exhibit various clinical behaviors. The study aims to understand the natural history, pathology, diagnostic workup, and treatment strategies for these tumors to improve patient outcomes. The audit included patients with salivary gland tumors detected through radiology or cytology. Patients underwent surgery, with some receiving adjuvant treatment. Demographic information, treatment interventions, and survival outcomes were analyzed using SPSS software. A total 89 as malignant salivart gland tumours were audited Malignant tumors were predominantly found in the parotid gland, with fewer cases in the minor salivary gland and submandibular gland.The median age of presentation was 47 years, and the majority of patients were male. The study examined various pathological and clinical factors, including tumor stage, nodal status, and the presence of facial palsy. Surgical procedures and histological types of tumors were documented. Adverse histological features like positive margins, lymph node positivity, lympho-vascular invasion, extracapsular spread, and perineural invasion were noted. POSTOP RT was administered to high-risk patients. Most malignant salivary gland tumors were found in the parotid gland, while minor salivary gland tumors were underrepresented in the audit. Surgical practices were diverse. Radiotherapy protocols were relatively standardized. The study found that certain histological features, such as lymph node positivity, margin positivity, lympho-vascular invasion, perineural invasion, and extracapsular spread, were associated with adverse effects on DFS and OS. The findings suggest that specific histological features, including LVI and ECE have emerged as independent prognostic factors for DFS and OS.
摘要：
涎腺肿瘤相对罕见，可以表现出各种临床行为。这项研究旨在了解自然史，病理学,诊断检查,和这些肿瘤的治疗策略，以改善患者的预后。审核包括通过放射学或细胞学检查发现的唾液腺肿瘤患者。患者接受了手术，一些人接受辅助治疗。人口统计信息,治疗干预措施,采用SPSS软件分析生存结局。总共有89例恶性唾液腺肿瘤被审计恶性肿瘤主要在腮腺发现，在小唾液腺和下颌下腺的病例较少。就诊年龄中位数为47岁,大多数患者是男性。该研究检查了各种病理和临床因素，包括肿瘤分期,节点状态，和面部麻痹的存在。记录了手术程序和肿瘤的组织学类型。不利的组织学特征，如阳性边缘，淋巴结阳性,淋巴管浸润,囊外扩散，并注意到神经周浸润。对高危患者进行术后RT。大多数恶性唾液腺肿瘤见于腮腺，而小唾液腺肿瘤在审计中的代表性不足。外科手术方式多种多样。放射治疗方案相对标准化。研究发现某些组织学特征,如淋巴结阳性，边缘积极性，淋巴管浸润,神经周浸润,囊外扩散，与DFS和OS的不良反应相关。研究结果表明，特定的组织学特征，包括LVI和ECE已成为DFS和OS的独立预后因素。
